34293-67-9

Basic information

• Product Name: methyl 3-hydroxy-2-methylbutanoate
• Synonyms: butanoic acid, 3-hydroxy-2-methyl-, methyl ester
• CAS NO: 34293-67-9
• Molecular Formula: C₆H₁₂O₃
• Molecular Weight: 132.1577
• Mol File: 34293-67-9.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 196°C at 760 mmHg
• Flash Point: 75.9°C
• Density: 1.021g/cm³
• Vapor Pressure: 0.105mmHg at 25°C
• Refractive Index: 1.425
• CAS DataBase Reference: methyl 3-hydroxy-2-methylbutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-hydroxy-2-methylbutanoate(34293-67-9)
• EPA Substance Registry System: methyl 3-hydroxy-2-methylbutanoate(34293-67-9)

Safety Data

• Hazardous Substances Data: 34293-67-9(Hazardous Substances Data)

Upstream product

• 17094-21-2 2-methyl-acetoacetic acid methyl ester 
• 53562-86-0 (S)-3-hydroxybutyric acid methyl ester 
• 74-88-4 methyl iodide 
• 207788-86-1 3,5-Dinitro-benzoic acid (1S,2R)-2-methoxycarbonyl-1-methyl-propyl ester 
• 78522-80-2 (2R,3S)-methyl 3-acetoxy-2-methylbutyrate 
• 67-56-1 methanol 
• 142061-17-4 (4R,5S,2'R,3'S)-4-cyclohexyl-3-(3-hydroxy-2-methylbutanoyl)-1,5-dimethylimidazolidin-2-one 
• 186581-53-3 diazomethane 
• 125664-99-5 N-<(2R,3S)-3-hydroxy-2-methylbutanoyl>bornane-10,2-sultam 
• 124-41-4 sodium methylate 
• 88635-99-8 (S)-3-((2S,3R)-3-Hydroxy-2-methyl-butyryl)-4-isopropyl-oxazolidin-2-one 
• 145163-07-1 (2S,3R)-3-Hydroxy-1-[(3S,4S)-5-((2S,3R)-3-hydroxy-2-methyl-butyryl)-1,1-dioxo-3,4-diphenyl-1λ⁶-[1,2,5]thiadiazolidin-2-yl]-2-methyl-butan-1-one 
• 74026-60-1 (+)-(2S,3R)-3-Acetoxy-2-methylbutansaeuremethylester 
• 101019-23-2 C₈H₁₄HgO₅ 

Downstream Products

• 868-57-5 methyl 2-methylbutanoate 
• 473-86-9 (+/-)-threo-3-Hydroxy-2-methylbuttersaeure 
• 17094-21-2 2-methyl-acetoacetic acid methyl ester 
• 5953-76-4 methyl angelate 
• 6622-76-0 methyl (E)-2-methyl-2-butenoate 
• 59056-73-4 (2S,3S,7R/S)-3,7-dimethylpentadecan-2-ol 
• 89968-94-5 p-Toluolsulfonsaeure-<(2S,3R)-3-hydroxy-2-methylbuthyl>ester 
• 69769-68-2 trans-(+/-)-stegobinone 
• 69769-68-2 (2R,3S,7RS)-(+)-stegobinone 
• 128252-98-2 chaetoviridin A 
• 99328-37-7 methyl (2S,3S)-3-(tert-butyldimethylsilyloxy)-2-methylbutanoate 
• 99328-40-2 methyl (2R,3S)-3-(tert-butyldimethylsilyloxy)-2-methylbutanoate 
• 92935-19-8 (2S,3S)-2-methyl-3-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)butyl 4-methylbenzenesulfonate 
• 69769-68-2 (2S,3R,7RS)-(-)-stegobinone 

Relevant articles and documents

SYNTHESIS OF (2S,3R,7RS)-STEGOBINONE (2,3-DIHYDRO-2,3,5-TRIMETHYL-6-(1-METHYL-2-OXOBUTYL)-4H-PYRAN-4-ONE) AND ITS (2R,3S,7RS)-ISOMER. THE PHEROMONE OF THE DRUGSTORE BEETLE

Reaction of acetaldehyde with the trianion of 4,6-dimethylnonane-3,5,7-trione followed by acidification yielded a stereoisomeric mixture of stegobinone, the pheromone of Stegobium paniceum L.Acylation of the dianion derived from 4-methylheptane-3,5-dione

Total Synthesis and Structural Revision of Chaetoviridins A

The first synthesis of the proposed structures of chaetoviridins A 1-4 has been achieved in 10 steps by controlling the syn- or anti-aldol side chain. The angular lactone has been regioselectively introduced by condensation of a chiral dioxin-4-one to cazisochromene. Comparison of the NMR and circular dichroism data of the synthesized and reported natural products led to the complete reassignment and renaming of the chaetoviridins.

Simple and efficient synthesis of (+)-methyl 7-benzoylpederate, a key intermediate toward the mycalamides

(equation presented) A simple and efficient method for the synthesis of (+)-methyl 7-benzoylpederate, the left half of pederin, mycalamides, onnamides, and theopederins, was developed. The key reactions include the Evans asymmetric aldol reaction, a thioa