34298-86-7

Basic information

• Product Name: RHEIN-8-GLUCOSIDE
• Synonyms: RHEIN-8-GLUCOSIDE;Rhein 8-O-glucoside;Glucorein;8-Glucosidorhein-9-anthrone;5-(beta-D-Glucopyranosyloxy)-9,10-dihydro-4-hydroxy-9,10-dioxo-2-anthracenecarboxylic acid;Rhein-8-O-glucopyranoside
• CAS NO: 34298-86-7
• Molecular Formula: C21H18O11
• Molecular Weight: 446.36
• Product Categories: Anthraquinones, Hydroquinones and Quinones
• Mol File: 34298-86-7.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility: DMSO (Slightly)
• CAS DataBase Reference: RHEIN-8-GLUCOSIDE(CAS DataBase Reference)
• NIST Chemistry Reference: RHEIN-8-GLUCOSIDE(34298-86-7)
• EPA Substance Registry System: RHEIN-8-GLUCOSIDE(34298-86-7)

Safety Data

• Hazardous Substances Data: 34298-86-7(Hazardous Substances Data)

Usage

Description

RHEIN-8-GLUCOSIDE is a naturally occurring compound found in the free state and as a glucoside in Rheum spp, Polygonaceae (rhubarb), and Senna leaves. It is an analog of Rhein (R318500) and is known for its cytotoxic and DNA-damaging properties towards both tumor and normal human cells. Additionally, RHEIN-8-GLUCOSIDE has been identified as an inhibitor of PTP1B (Human Protein Tyrosine Kinase 1B) in vitro and serves as a potential antioxidant resource, particularly from endophytic fungi in medicinal plants. This substance is a primary reference substance with assigned absolute purity, taking into account chromatographic purity, water, residual solvents, and inorganic impurities.

Uses

Used in Pharmaceutical Applications:
RHEIN-8-GLUCOSIDE is used as a cytotoxic agent for its DNA-damaging properties towards tumor and normal human cells, making it a potential candidate in the development of cancer treatments.
Used in Enzyme Inhibition:
RHEIN-8-GLUCOSIDE is used as an inhibitor of PTP1B (Human Protein Tyrosine Kinase 1B) in vitro, which may have implications in the treatment of various diseases and conditions related to the dysregulation of this enzyme.
Used in Antioxidant Research:
RHEIN-8-GLUCOSIDE is used as a potential antioxidant resource, particularly derived from endophytic fungi in medicinal plants, which could be beneficial in the development of novel antioxidant therapies and supplements.
Used in Chemical and Analytical Research:
As a primary reference substance with assigned absolute purity, RHEIN-8-GLUCOSIDE is used in various chemical and analytical research applications to ensure accurate and reliable results in experiments and studies.