343-04-4

Basic information

• Product Name: 2-BROMO-1-(5-FLUORO-2-METHOXYPHENYL)ETHANONE
• Synonyms: 2-Bromo-1-(5-fluoro-2-methoxyphenyl)ethan-1-one;a-BroMo-5'-fluoro-2'-Methoxyacetophenone;2-Bromo-5′-fluoro-2′-methoxyacetophenone
• CAS NO: 343-04-4
• Molecular Formula: C₉H₈BrFO₂
• Molecular Weight: 247.06
• Mol File: 343-04-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 75-80°C
• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-BROMO-1-(5-FLUORO-2-METHOXYPHENYL)ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-1-(5-FLUORO-2-METHOXYPHENYL)ETHANONE(343-04-4)
• EPA Substance Registry System: 2-BROMO-1-(5-FLUORO-2-METHOXYPHENYL)ETHANONE(343-04-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 343-04-4(Hazardous Substances Data)

Usage

General Description

2-BROMO-1-(5-FLUORO-2-METHOXYPHENYL)ETHANONE is a chemical compound with the molecular formula C9H8BrFO2. It is an organic compound that contains a bromine atom, a fluorine atom, and a methoxy group attached to a phenyl ring. 2-BROMO-1-(5-FLUORO-2-METHOXYPHENYL)ETHANONE is commonly used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and fine chemicals. It is a versatile intermediate that can be used in the production of a wide range of organic compounds. This chemical is also used in research and development for creating new drugs and compounds with potential therapeutic applications.

Upstream product

• 445-82-9 1-(5-fluoro-2-methoxyphenyl)ethanone 
• 459-60-9 1-fluoro-4-methoxybenzene 
• 598-21-0 2-Bromoacetyl bromide 

Downstream Products

• 394-82-1 2-(5-fluoro-2-methoxy-phenyl)-7-methyl-indolizine 
• 390-55-6 2-(5-fluoro-2-methoxy-phenyl)-quinoxaline 
• 801154-59-6 1-(5-fluoro-2-methoxy-phenyl)-2-(2-imino-thiazolidin-3-yl)-ethanone 
• 1545-90-0 6-(5-fluoro-2-methoxy-phenyl)-imidazo[2,1-b]thiazole 
• 1496-22-6 ethyl-[4-(5-fluoro-2-methoxy-phenyl)-thiazol-2-yl]-amine 
• 715-89-9 2-Amino-4-<5-fluor-2-methoxyphenyl>-thiazol 
• 1547-71-3 [4-(5-fluoro-2-methoxy-phenyl)-thiazol-2-yl]-phenyl-amine 
• 887591-34-6 C₁₀H₈FNO₂ 
• 934340-27-9 C₁₃H₁₂FNO₄ 
• 6752-10-9 2-(2-acetylimino-thiazolidin-3-yl)-1-(5-fluoro-2-methoxy-phenyl)-ethanol 
• 1213240-82-4 2-(5-fluoro-2-methoxyphenyl)-8,9-dimethoxy-1-(3,4,5-trimethoxyphenyl)-5,6-dihydropyrrolo[2,1-a]isoquinoline 
• 1213240-83-5 2-(5-fluoro-2-methoxyphenyl)-8-isopropoxy-1-(4-isopropoxy-3-methoxyphenyl)-9-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline 
• 1213240-84-6 2-(5-fluoro-2-methoxyphenyl)-8,9-dimethoxy-1-(4-methoxyphenyl)-5,6-dihydropyrrolo[2,1-a]isoquinoline 

Relevant articles and documents

Preparation method of 2-methoxy-5-fluorobromoacetophenone

The invention discloses a preparation method of 2-methoxy-5-fluorobromoacetophenone. The method comprises the following steps: taking p-fluoroanisole as an initial raw material, and reacting with bromoacetyl bromide under the condition of Lewis acid to generate a compound I, namely 2-methoxy-5-fluorobromoacetophenone. In the one-step synthesis route process taking the p-fluoroanisole as the initial raw material, a large amount of reagents with high toxicity and high pollution are avoided, and meanwhile, the raw materials are low in price, so that the whole synthesis process is low in pollution and easy to treat.

Novel hybrids from lamellarin D and combretastatin A 4 as cytotoxic agents

A new series of hybrids of lamellarin D and combretastatin A 4, 1,2-diphenyl-5,6-dihydropyrrolo [2,1-a] isoquinolines, were designed as cytotoxic agents based on principles of combination in medicinal chemistry and taking the parent compounds' different anti-proliferative mechanisms into consideration. Twenty-two novel hybrids were synthesized through a convenient route, with a key step of core pyrrole formation and evaluated for their anti-proliferative activities in vitro against K-562, A-549, SMMC-7721, SGC-7901 and HCT-116 cancer cell lines. The results showed that some hybrids had good anti-proliferative activities in low IC50 ranges.