343-21-5

Basic information

• Product Name: 4-(Trifluoromethyl)-10H-phenothiazine
• Synonyms: 4-(Trifluoromethyl)-10H-phenothiazine
• CAS NO: 343-21-5
• Molecular Formula: C₁₃H₈F₃NS
• Molecular Weight: 267.27
• Mol File: 343-21-5.mol
• Article Data: 0

Chemical Properties

• Melting Point: 72-73 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 354.6°C at 760 mmHg
• Flash Point: 168.3°C
• Appearance: /
• Density: 1.369g/cm³
• Vapor Pressure: 3.31E-05mmHg at 25°C
• Refractive Index: 1.588
• PKA: -2.50±0.20(Predicted)
• CAS DataBase Reference: 4-(Trifluoromethyl)-10H-phenothiazine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Trifluoromethyl)-10H-phenothiazine(343-21-5)
• EPA Substance Registry System: 4-(Trifluoromethyl)-10H-phenothiazine(343-21-5)

Safety Data

• Hazardous Substances Data: 343-21-5(Hazardous Substances Data)

Usage

Description

4-(Trifluoromethyl)-10H-phenothiazine is a chemical compound derived from phenothiazine, which is a key component in the development of antipsychotic and antihistaminic drugs. 4-(Trifluoromethyl)-10H-phenothiazine features a trifluoromethyl group attached to the phenothiazine structure, which may contribute to its unique properties and potential applications.

Uses

Used in Pharmaceutical Industry:
4-(Trifluoromethyl)-10H-phenothiazine is used as an active pharmaceutical ingredient for the development of antipsychotic and antihistaminic drugs. Its trifluoromethyl substitution may enhance the compound's pharmacological properties, such as potency, selectivity, and bioavailability, leading to improved therapeutic outcomes in the treatment of various psychiatric and allergic disorders.
Used in Research and Development:
In the field of medicinal chemistry, 4-(Trifluoromethyl)-10H-phenothiazine serves as a valuable research compound for exploring the structure-activity relationships of phenothiazine derivatives. This knowledge can be applied to design and synthesize novel drugs with improved efficacy and safety profiles for various therapeutic applications.
Used in Drug Delivery Systems:
Similar to gallotannin, 4-(Trifluoromethyl)-10H-phenothiazine may also benefit from novel drug delivery systems to enhance its delivery, bioavailability, and therapeutic outcomes. By employing various organic and metallic nanoparticles as carriers, the compound's efficacy against specific targets can be improved, potentially leading to more effective treatments for various conditions.

InChI:InChI=1/C13H8F3NS/c14-13(15,16)8-4-3-6-10-12(8)18-11-7-2-1-5-9(11)17-10/h1-7,17H

Upstream product

• 101-23-5 N-(3-trifluoromethylphenyl)aniline