343-62-4

Basic information

• Product Name: Ethanone, 2-bromo-1-(4-fluoro-2-methylphenyl)-
• CAS NO: 343-62-4
• Molecular Formula: C9H8BrFO
• Molecular Weight: 231.064
• Mol File: 343-62-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Ethanone, 2-bromo-1-(4-fluoro-2-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-bromo-1-(4-fluoro-2-methylphenyl)-(343-62-4)
• EPA Substance Registry System: Ethanone, 2-bromo-1-(4-fluoro-2-methylphenyl)-(343-62-4)

Safety Data

• Hazardous Substances Data: 343-62-4(Hazardous Substances Data)

Usage

General Description

Ethanone, 2-bromo-1-(4-fluoro-2-methylphenyl)- is a chemical compound with the molecular formula C10H9BrFO. It is also known as 4’-Fluoro-2’-methyl-1-bromoacetophenone. It is a ketone compound consisting of a bromine atom, a fluoro-substituted phenyl group, and a methyl group attached to the carbonyl carbon. This chemical is commonly used in organic synthesis as an intermediate in the production of pharmaceuticals, agrochemicals, and other fine chemicals. It is also used in research laboratories for various applications. Eminently it acts as a synthetic building block for pharmaceutical compounds.

Upstream product

• 446-29-7 1-(4-fluoro-2-methylphenyl)ethanone 
• 700-34-5 (RS)-1-(4-fluoro-2-methylphenyl)ethanol 
• 63082-45-1 4-fluoro-2-methylbenzaldehyde 
• 352-70-5 m-Fluorotoluene 

Downstream Products

• 78864-12-7 (4-ethoxy-phenyl)-[5-(4-fluoro-2-methyl-phenyl)-thiazol-2-yl]-amine 
• 78864-13-8 [5-(4-fluoro-2-methyl-phenyl)-thiazol-2-yl]-(2-methoxy-phenyl)-amine 
• 1415838-39-9 8-bromo-7-(2-(4-fluoro-2-methylphenyl)-2-oxoethyl)-3-methyl-1H-purine-2,6(3H,7H)-dione 
• 1232039-54-1 C₁₃H₈Br₂FN₃ 
• 79101-44-3 (4-fluoro-2-methylbenzoyl) acetyl methylene triphenylarsorane 
• 79101-38-5 1-(4-Fluoro-2-methyl-phenyl)-2-(triphenyl-λ⁵-arsanylidene)-ethanone 
• 79101-40-9 (E)-3-(3,4-Dimethoxy-phenyl)-1-(4-fluoro-2-methyl-phenyl)-propenone 
• 79101-39-6 (E)-3-(4-Chloro-phenyl)-1-(4-fluoro-2-methyl-phenyl)-propenone 
• 443-19-6 4-dimethylamino-4'-fluoro-2'-methyl-trans-chalcone 
• 79101-35-2 (4-fluoro-2-methylphenacyl)-triphenylarsonium bromide 
• 76609-14-8 N-(4-Fluoro-2-methylphenacyl)pyridinium bromide 
• 78864-11-6 (4-bromo-phenyl)-[5-(4-fluoro-2-methyl-phenyl)-thiazol-2-yl]-amine 
• 394-86-5 2-(4-fluoro-2-methyl-phenyl)-7-methyl-indolizine 
• 394-85-4 2-(4-fluoro-2-methyl-phenyl)-5-methyl-indolizine 

Relevant articles and documents

Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors

Autotaxin (ATX) is a secreted enzyme playing a major role in the production of lysophosphatidic acid (LPA) in blood through hydrolysis of lysophosphatidyl choline (LPC). The ATX-LPA signaling axis arouses a high interest in the drug discovery industry as it has been implicated in several diseases including cancer, fibrotic diseases, and inflammation, among others. An imidazo[1,2-a]pyridine series of ATX inhibitors was identified out of a high-throughput screening (HTS). A cocrystal structure with one of these compounds and ATX revealed a novel binding mode with occupancy of the hydrophobic pocket and channel of ATX but no interaction with zinc ions of the catalytic site. Exploration of the structure-activity relationship led to compounds displaying high activity in biochemical and plasma assays, exemplified by compound 40. Compound 40 was also able to decrease the plasma LPA levels upon oral administration to rats.

Novel 5-HT2A receptor ligands

Compounds of formula I: are antagonists of the human 5-HT2A receptor, and hence useful in treatment or prevention of a variety of neurological conditions.