343244-28-0

Basic information

• Product Name: 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-pyridinyl)pyrrolidine
• CAS NO: 343244-28-0
• Molecular Weight: 454.359
• Mol File: 343244-28-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-pyridinyl)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-pyridinyl)pyrrolidine(343244-28-0)
• EPA Substance Registry System: 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-pyridinyl)pyrrolidine(343244-28-0)

Safety Data

• Hazardous Substances Data: 343244-28-0(Hazardous Substances Data)

Upstream product

• 343240-67-5 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid 
• 66269-75-8 4-(pyrrolidin-2-yl)pyridine 

Relevant articles and documents

Pyrrolidine amides of pyrazolodihydropyrimidines as potent and selective KV1.5 blockers

Design and synthesis of pyrazolodihydropyrimidines as KV1.5 blockers led to the discovery of 7d as a potent and selective antagonist. This compound showed atrial selective prolongation of effective refractory period in rabbits and was selected for clinical development.