343564-14-7

Basic information

• Product Name: 1-(4-Amino-3-trifluoromethyl-phenyl)-ethanone
• Synonyms: 1-(4-Amino-3-trifluoromethyl-phenyl)-ethanone;Ethanone,1-[4-amino-3-(trifluoromethyl)phenyl]-
• CAS NO: 343564-14-7
• Molecular Formula: C₉H₈F₃NO
• Molecular Weight: 203.16
• Mol File: 343564-14-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 271.857 °C at 760 mmHg
• Flash Point: 118.215 °C
• Appearance: /
• Density: 1.296 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 1-(4-Amino-3-trifluoromethyl-phenyl)-ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Amino-3-trifluoromethyl-phenyl)-ethanone(343564-14-7)
• EPA Substance Registry System: 1-(4-Amino-3-trifluoromethyl-phenyl)-ethanone(343564-14-7)

Safety Data

• Hazardous Substances Data: 343564-14-7(Hazardous Substances Data)

Usage

Description

1-(4-Amino-3-trifluoromethyl-phenyl)-ethanone is a chemical compound with a molecular formula C8H8F3NO. It is an ethanone derivative featuring a trifluoromethyl group attached to the phenyl ring and an amino group at the para position. 1-(4-Amino-3-trifluoromethyl-phenyl)-ethanone is known for its versatile reactivity and its role as a building block for more complex molecules in the synthesis of pharmaceuticals and agrochemicals. The presence of the trifluoromethyl group endows it with unique properties, making it a valuable tool in drug discovery and development.

Uses

Used in Pharmaceutical Industry:
1-(4-Amino-3-trifluoromethyl-phenyl)-ethanone is used as a synthetic intermediate for the development of various pharmaceuticals. Its unique structure and reactivity allow for the creation of new drug candidates with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 1-(4-Amino-3-trifluoromethyl-phenyl)-ethanone is utilized as a key component in the synthesis of pesticides and other agrochemical products. Its ability to be incorporated into complex molecules contributes to the development of effective and innovative solutions for agricultural challenges.
Used in Drug Discovery and Development:
1-(4-Amino-3-trifluoromethyl-phenyl)-ethanone is employed as a valuable tool in drug discovery and development due to its unique properties and reactivity. The trifluoromethyl group can impart specific characteristics to molecules, aiding researchers in the design and synthesis of novel therapeutic agents.

Upstream product

• 343564-13-6 1-[4-nitro-3-(trifluoromethyl)phenyl]-1-ethanone 
• 887144-94-7 Togni's reagent II 
• 99-92-3 p-aminobenzophenone 

Relevant articles and documents

Transition metal-free direct C–H trifluoromethyltion of (hetero)arenes with Togni's reagent

A new transition-metal-free direct C–H trifluoromethylation reaction of (hetero)arenes with Togni's reagent was developed. This transformation proceeded smoothly under mild conditions and exhibited good tolerance of many synthetically relevant functional groups. It provided an alternative approach for the synthesis of trifluoromethylated (hetero)arenes.

Nickel-Catalyzed Direct C-H Trifluoromethylation of Free Anilines with Togni's Reagent

An efficient nickel-catalyzed C-H trifluoromethylation for the synthesis of trifluoromethylated free anilines using Togni's reagent has been developed. This approach exhibits a good functional group tolerance, good regioselectivity, and chemoselectivity under mild conditions. The newly developed economical one-step method is a better alternative to synthesize trifluoromethylated free anilines.

A for the preparation of ortho-trifluoromethyl-aniline or its derivatives (by machine translation)

The invention discloses a method for preparing o-trifluoromethyl phenylamine and derivatives thereof. According to the method, phenylamine or a phenylamine derivative serving as raw material reacts with a trivalent iodine reagent compound 2 in a solution under the protection of argon or nitrogen and illumination condition in the presence of tri(2-phenylpyridine)-iridium [Ir(ppy)3] serving as a catalyst to produce o-trifluorophenylamine or derivatives thereof 3, wherein the trivalent iodine reagent compound 2 has a structure shown in the specification. The method is mild in reaction conditions, the amino does not need to be protected, and trifluoromethyl substituted phenylamine or phenylamine derivatives can be directly obtained.