34367-04-9 Usage
Description
Ginsenoside Ro is a non-steroid glycoside found in plants of the genus Panax, known for its anti-inflammatory, antithrombotic, and antiviral properties. It exhibits various biological activities, such as inhibiting the release of reactive oxygen species (ROS) and nitric oxide (NO), as well as suppressing inducible nitric oxide synthase (iNOS) and COX-2 protein expression in RAW 264.7 murine macrophages. Ginsenoside Ro also dose-dependently inhibits human platelet aggregation and thrombin-induced disseminated intravascular coagulation (DIC) in rats, and enhances the survival rate of Sendai virus-infected mice when administered at specific concentrations.
Uses
Used in Pharmaceutical Applications:
Ginsenoside Ro is used as an anti-inflammatory agent for its ability to inhibit LPS-induced release of ROS and NO, as well as iNOS and COX-2 protein expression in murine macrophages. This makes it a potential candidate for treating inflammation-related conditions.
Used in Cardiovascular Applications:
Ginsenoside Ro is used as an antithrombotic agent for its dose-dependent inhibition of human platelet aggregation and thrombin-induced DIC in rats, which could be beneficial in managing and preventing blood clot-related disorders.
Used in Antiviral Applications:
Ginsenoside Ro is used as an antiviral agent for its ability to increase the survival rate of Sendai virus-infected mice when administered at a specific dose, suggesting its potential use in treating viral infections.
Used in Cosmeceutical Applications:
Ginsenoside Ro is used as a hair regrowth stimulator for its ability to stimulate hair regrowth after shaving in a mouse model of slowed hair regrowth, making it a potential ingredient in hair growth promotion products.
Used in Traditional Medicine:
Ginsenoside Ro, being a natural product found in Panax japonicus var. major, is used in traditional medicine for its various health-promoting properties, including its anti-inflammatory, antithrombotic, and antiviral activities.
Check Digit Verification of cas no
The CAS Registry Mumber 34367-04-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,4,3,6 and 7 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 34367-04:
(7*3)+(6*4)+(5*3)+(4*6)+(3*7)+(2*0)+(1*4)=109
109 % 10 = 9
So 34367-04-9 is a valid CAS Registry Number.
InChI:InChI=1/C48H76O19/c1-43(2)14-16-48(42(61)67-40-35(58)31(54)29(52)24(20-50)63-40)17-15-46(6)21(22(48)18-43)8-9-26-45(5)12-11-27(44(3,4)25(45)10-13-47(26,46)7)64-41-37(33(56)32(55)36(65-41)38(59)60)66-39-34(57)30(53)28(51)23(19-49)62-39/h8,22-37,39-41,49-58H,9-20H2,1-7H3,(H,59,60)/t22-,23-,24-,25?,26?,27?,28-,29-,30+,31+,32+,33+,34-,35-,36+,37-,39+,40+,41-,45+,46-,47-,48+/m1/s1
34367-04-9Relevant articles and documents
Facile Synthesis of Ginsenoside Ro
Peng, Wenjie,Sun, Jiansong,Lin, Feng,Han, Xiuwen,Yu, Biao
, p. 259 - 262 (2007/10/03)
Two concise synthetic routes, being different in the glycosylation sequence, toward ginsenoside Ro (1) are developed. These syntheses feature the elaboration of the glucuronide residue at a later stage via the TEMPO-mediated selective oxidation and the installation of AZMB as a benzoylic neighboring participating group capable of being selectively removed afterward.
