343781-45-3 Usage
General Description
4-Bromo-3,5-dichloropyridine is a chemical compound with the formula C5H2BrCl2N. It is a heterocyclic organic compound that consists of a pyridine ring with bromine and two chlorine substituents. 4-BROMO-3,5-DICHLOROPYRIDINE is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also used as an intermediate in the manufacturing of various chemical products. 4-Bromo-3,5-dichloropyridine is a white to light yellow crystalline powder that is sparingly soluble in water but soluble in organic solvents. It is important to handle this compound with caution, as it may have hazardous effects on human health and the environment if not properly managed.
Check Digit Verification of cas no
The CAS Registry Mumber 343781-45-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,3,7,8 and 1 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 343781-45:
(8*3)+(7*4)+(6*3)+(5*7)+(4*8)+(3*1)+(2*4)+(1*5)=153
153 % 10 = 3
So 343781-45-3 is a valid CAS Registry Number.
InChI:InChI=1/C5H2BrCl2N/c6-5-3(7)1-9-2-4(5)8/h1-2H
343781-45-3Relevant articles and documents
Strategies for the selective functionalization of dichloropyridines at various sites
Marzi, Elena,Bigi, Anna,Schlosser, Manfred
, p. 1371 - 1376 (2007/10/03)
Whereas 2,3-dichloropyridine and 2,5-dichloro-4-(lithiooxy)-pyridine undergo deprotonation exclusively at the 4- and 2-positions, respectively, optional site selectivity can be implemented with 2,5- and 3,4-dichloropyridine (which are attacked, depending on the choice of the reagents, at either the 4- or 6- and either the 2- and 5-positions, respectively). Upon treatment with lithium diisopropylamide, 2,4-dichloro-3-iodopyridine, 3,5-dichloro-4-bromopyridine and 2,6-dichloro-3-iodopyridine afford 5-, 2- and 4-lithiated intermediates, but the latter isomerize instantaneously to species in which lithium and iodine have swapped places, the driving force being the low basicity of C-Li bonds when flanked by two neighboring halogens.
