343781-49-7 Usage
General Description
Pyridine, 2,4-dichloro-5-iodo-, also known as 2,4-dichloro-5-iodopyridine, is a chemical compound with the molecular formula C5H2Cl2IN. It is a halogenated pyridine derivative that is used in the synthesis of pharmaceuticals and agricultural chemicals. It is commonly utilized as an intermediate in the production of pharmaceuticals such as antiviral and anticancer drugs, as well as in the development of agrochemicals and specialized chemicals. Pyridine, 2,4-dichloro-5-iodo- is also used in research and development for its unique properties and as a building block for the production of more complex organic compounds. Despite its usefulness, it is important to handle this compound with care, as it is classified as a hazardous material due to its potentially harmful effects on human health and the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 343781-49-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,3,7,8 and 1 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 343781-49:
(8*3)+(7*4)+(6*3)+(5*7)+(4*8)+(3*1)+(2*4)+(1*9)=157
157 % 10 = 7
So 343781-49-7 is a valid CAS Registry Number.
InChI:InChI=1/C5H2Cl2IN/c6-3-1-5(7)9-2-4(3)8/h1-2H
343781-49-7Relevant articles and documents
Development of a Scalable Synthesis for the Potent Kinase Inhibitor BMS-986236; 1-(5-(4-(3-Hydroxy-3-methylbutyl)-1 H-1,2,3-triazol-1-yl)-4-(isopropylamino)pyridin-2-yl)-1 H-pyrazolo[3,4- b]pyridine-5-carbonitrile
Arunachalam, Pirama Nayagam,Kuppusamy, Prakasam,Ganesan, Sivakumar,Krishnamoorthy, Suresh,Nimje, Roshan Y.,Jarugu, Lokesh Babu,Kanikahalli Chikkananjaiah, Nanjundaswamy,Anki Reddy, China,Anjanappa, Prakash,Botlagunta, Murali,Vanteru, Sridhar,Maddala, Nageswararao,Shankar, Muniyappa,Nair, Satheesh,Hynes, John,Santella, Joseph B.,Carter, Percy H.,Rampulla, Richard,Vetrichelvan, Muthalagu,Gupta, Anuradha,Gupta, Arun Kumar,Mathur, Arvind
supporting information, p. 912 - 918 (2019/05/06)
A scalable route to 1-(5-(4-(3-hydroxy-3-methylbutyl)-1H-1,2,3-triazol-1-yl)-4-(isopropylamino)pyridin-2-yl)-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile (1, BMS-986236) was developed by incorporating an alternate azide intermediate following safety-driven processes. The newly developed process involved mitigating safety hazards and eliminating the column chromatography purification. The issue of trace metal contamination in the final API observed in the first-generation synthesis has been overcome.
