3439-73-4Relevant articles and documents
Calcium ion fluorescent probe based on aggregation-induced effect and preparation method and application thereof
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Paragraph 0029; 0030; 0031, (2020/04/17)
The present invention proposes a soluble tetraphenylethylene-based fluorescent probe represented by a structure formula (I), wherein the soluble tetraphenylethylene-based fluorescent probe can performhigh-selectivity fluorescence detection on Ca, is not interfered by other metal ions, has advantages of wide pH value range, good water solubility and high sensitivity, can be used for the selective detection of Ca in environmental and biological samples, and has a certain application prospect in the diagnosis of Ca related diseases. The formula (I) is defined in the specification.
Stereoselectivity of methyl aryldiazoacetate cyclopropanations of 1,1-diarylethylene. Asymmetric synthesis of a cyclopropyl analogue of tamoxifen.
Davies,Nagashima,Klino 3rd.
, p. 823 - 826 (2007/10/03)
[formula: see text] Dirhodium tetrakis(S-(N-dodecylbenzenesulfonyl)prolinate) (Rh2(S-DOSP)4)-catalyzed decomposition of methyl phenyldiazoacetate in the presence of 1,1-diarylethylenes results in intermolecular cyclopropanation with high enantioselectivity (up to 99% ee) and moderate diastereoselectivity (up to 80% de). The reaction was applied to the asymmetric synthesis of a cyclopropyl analogue of tamoxifen.
Synthesis and pharmacology of basic sec, tert alcohols and derivatives (Japanese)
Igarashi,Kurihara
, p. 554 - 565 (2007/10/05)
In order to investigate the relation between chemical structure and pharmacological properties, 68 new compounds belonging to amino alcohol derivatives were synthesized. One of them showed twice as potent an analgesic activity as barbipyrine, and five of them were found to be as effective as barbipyrine. Antispasmodic activity was recognized in the solution of these compounds at the concentration from 10-4 to 10-7 g/ml. Almost all the compounds were shown to have local anesthetic activity and the duration of the activity of several substances was more than 120 min. In general, the pharmacological activity decreased in the order of aminoolefins, urethans, amino alcohols, and alkamine esters.