344-14-9Relevant articles and documents
FACILE SYNTHESIS OF DIALKYL FLUOROMALONATES AND THEIR DERIVATIVES
Ishikawa, Nobuo,Takaoka, Akio
, p. 107 - 110 (1981)
Dimethyl and diethyl fluoromalonates were prepared by the stepwise basic alcoholysis of hexafluoropropene in a total yield of 50 - 55 percent.These dialkyl fluoromalonates were alkylated with alkyl halides, and the resulting dialkyl α-fluoroalkylmalonates were cyclized with urea affording 5-fluorobarbituric acid derivatives.
Electrochemical Intermolecular Monofluoroalkylation of α,β-Unsaturated Carboxylic Acids and Heteroaromatics with 2-Fluoromalonate Esters
Hou, Zhong-Wei,Jiang, Ting,Wang, Lei,Wu, Ting-Xia
supporting information, p. 8585 - 8589 (2021/11/17)
An electrochemical approach for the preparation of monofluorides from α,β-unsaturated carboxylic acids and heteroaromatics with readily available 2-fluoromalonate esters as monofluoroalkyl radical precursors has been developed. The electrosynthesis employs ferrocene (Cp2Fe) as a catalyst in a simple undivided cell with a broad substrate scope, which obviates the need for sacrificial oxidizing reagents.
Preparation method of dimethyl 2-fluoromalonate
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Paragraph 0024-0041, (2019/06/30)
The invention belongs to the technical field of chemical synthesis, and particularly relates to a preparation method of dimethyl 2-fluoromalonate. The preparation method of the dimethyl 2-fluoromalonate comprises the following steps: (1) uniformly mixing and stirring 4-5 mol parts of dioxane, 1 mol part of dimethyl chloromalonate and 0.01-0.05 mol part of potassium iodide in a reaction vessel; (2)adding 1-1.5 mol parts of dried and activated potassium fluoride into the reaction vessel; (3) heating to carry out reflux reaction while stirring; (4) collecting fractions at the temperature of 74-78 DEG C; (5) stopping heating when the distillation temperature reaches 78 DEG C to obtain a crude product of dimethyl 2-fluoromalonate; and (6) refining the crude product of dimethyl 2-fluoromalonateto obtain a target product. The method is controllable in process, high in yield and low in cost.
Preparation method for fluoromalonic acid diester
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Paragraph 0046-0048, (2018/06/15)
The invention especially relates to a preparation method for fluoromalonic acid diester, belonging to the field of organic synthesis. The preparation method comprises a step of subjecting fluoroacetate and dialkyl carbonate to a condensation reaction in the presence of alkali so as to prepare fluoromalonic acid diester. The preparation method provided by the invention is mild in reaction process;the preparation method has low toxicity and corrosivity due to elimination of conventional chlorination and fluorination steps; and the preparation method does not produce difluoromalonic acid diesterimpurities, has low requirements on factory equipment and is simple and safe to operate.