34402-92-1

Basic information

• Product Name: Propanedioic acid, (4-chlorophenyl)-, dimethyl ester
• CAS NO: 34402-92-1
• Molecular Formula: C11H11ClO4
• Molecular Weight: 242.659
• Mol File: 34402-92-1.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, (4-chlorophenyl)-, dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, (4-chlorophenyl)-, dimethyl ester(34402-92-1)
• EPA Substance Registry System: Propanedioic acid, (4-chlorophenyl)-, dimethyl ester(34402-92-1)

Safety Data

• Hazardous Substances Data: 34402-92-1(Hazardous Substances Data)

Upstream product

• 1878-66-6 4-chlorophenylacetic Acid 
• 52449-43-1 (4-chloro-phenyl)-acetic acid methyl ester 
• 616-38-6 carbonic acid dimethyl ester 
• 108-90-7 chlorobenzene 
• 108-59-8 malonic acid dimethyl ester 
• 553-90-2 Dimethyl oxalate 

Downstream Products

• 3974-10-5 <4-Chlor-phenyl>-malonsaeure-amid 
• 118459-48-6 2-(4-chlorophenyl)propanedioic acid 
• 441798-36-3 C₁₉H₂₀BrClN₆O₄S 
• 441795-23-9 C₂₃H₂₀BrClN₆O₄S 
• 441795-22-8 C₁₉H₁₉ClN₄O₄S 

Relevant articles and documents

Palladium-Catalyzed Asymmetric Allylic Alkylation of 4-Substituted Isoxazolidin-5-ones: Straightforward Access to β2,2-Amino Acids

We report here an unprecedented and highly enantioselective palladium-catalyzed allylic alkylation applied to 4-substituted isoxazolidin-5-ones. Ultimately, the process provides a straightforward access to β2,2-amino acids bearing an all-carbon quaternary stereogenic center in great yields and a high degree of enantioselectivity.

Gold(I)-Catalyzed Enantioselective Desymmetrization of 1,3-Diols through Intramolecular Hydroalkoxylation of Allenes

A gold(I)-catalyzed enantioselective desymmetrization of 1,3-diols was achieved by intramolecular hydroalkoxylation of allenes. The catalyst system 3-F-dppe(AuCl)2 /(R)-C8-TRIPAg proved to be specifically efficient to promote the desymmetrizing cyclization of 2-aryl-1,3-diols, which have proven challenging substrates in previous reports. Multisubstituted tetrahydrofurans were prepared in good yield with good enantioselectivity and diastereoselectivity by this method.

4-Amino-5-aryl-6-arylethynylpyrimidines: Structure-activity relationships of non-nucleoside adenosine kinase inhibitors

A series of non-nucleoside adenosine kinase (AK) inhibitors is reported. These inhibitors originated from the modification of 5-(3-bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-ylamine (ABT-702). The identification of a linker that would approximate the spatial arrangement found between the pyrimidine ring and the aryl group at C(7) in ABT-702 was a key element in this modification. A search of potential linkers led to the discovery of an acetylene moiety as a suitable scaffold. It was hypothesized that the aryl acetylenes, ABT-702, and adenosine bound to the active site of AK (closed form) in a similar manner with respect to the orientation of the heterocyclic base. Although potent acetylene analogs were discovered based on this assumption, an X-ray crystal structure of 5-(4-dimethylaminophenyl)-6-(6-morpholin-4-ylpyridin-3-ylethynyl)pyrimidin-4-ylamine (16a) revealed a binding orientation contrary to adenosine. In addition, this compound bound tightly to a unique open conformation of AK. The structure-activity relationships and unique ligand orientation and protein conformation are discussed.