344348-28-3 Usage
Description
5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-carboxylic Acid Methyl Ester is an organic compound that serves as an intermediate in the biosynthesis of Ochratoxin A, a toxic metabolite produced by Aspergillus ochraceus.
Uses
Used in Chemical Research:
5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-carboxylic Acid Methyl Ester is used as a research compound for studying the biosynthesis of Ochratoxin A and its potential applications in various fields.
Used in Pharmaceutical Industry:
5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-carboxylic Acid Methyl Ester is used as an intermediate in the synthesis of pharmaceutical compounds, particularly those targeting fungal infections and related diseases.
Used in Environmental Monitoring:
5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-carboxylic Acid Methyl Ester can be used as a biomarker for detecting the presence of Aspergillus ochraceus and Ochratoxin A in environmental samples, such as food products and agricultural commodities, to ensure safety and quality standards.
Check Digit Verification of cas no
The CAS Registry Mumber 344348-28-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,4,3,4 and 8 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 344348-28:
(8*3)+(7*4)+(6*4)+(5*3)+(4*4)+(3*8)+(2*2)+(1*8)=143
143 % 10 = 3
So 344348-28-3 is a valid CAS Registry Number.
344348-28-3Relevant articles and documents
Click Chemistry-Assisted Bioconjugates for Hapten Immunodiagnostics
López-Puertollano, Daniel,Agulló, Consuelo,Mercader, Josep V.,Abad-Somovilla, Antonio,Abad-Fuentes, Antonio
, p. 956 - 964 (2020/04/09)
Bioorthogonal reactions have revolutionized the way low-molecular-weight compounds are coupled to biomolecules. Organic chemistry, polymer science, and chemical biology are among the disciplines that have benefited the most from this breakthrough. Despite the reliability of the click chemistry concept for the efficient and chemoselective functionalization of biomacromolecules with haptens at preferred positions, the fact that azide-alkyne cycloaddition reactions originate new chemical moieties as part of the linker may have delayed their application in the immunodiagnostic field. Using the mycotoxin ochratoxin A as a model compound, we herein demonstrate for the first time that bioconjugates arising from the ligation between an azido-bearing hapten and an alkyne-modified carrier protein are able to elicit the generation of high-affinity monoclonal antibodies suitable for the development of rapid methods for the immunodetection of small organic molecules.
