344350-71-6

Basic information

• Product Name: 4-(4-methylphenyl)-2-phenylfuran
• Synonyms: 4-(4-methylphenyl)-2-phenylfuran
• CAS NO: 344350-71-6
• Molecular Weight: 234.298
• Mol File: 344350-71-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-(4-methylphenyl)-2-phenylfuran(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-methylphenyl)-2-phenylfuran(344350-71-6)
• EPA Substance Registry System: 4-(4-methylphenyl)-2-phenylfuran(344350-71-6)

Safety Data

• Hazardous Substances Data: 344350-71-6(Hazardous Substances Data)

Upstream product

• 69626-39-7 1-phenylbuta-2,3-dien-1-one 
• 5720-05-8 4-methylphenylboronic acid 
• 1379820-13-9 4-p-methylphenyl-1,2-oxaborol-2(5H)-ol 
• 93-97-0 benzoic acid anhydride 
• 122-00-9 para-methylacetophenone 
• 20442-65-3 1-(4-methylphenyl)-3-phenylprop-2-yn-1-one 

Relevant articles and documents

β-Bromoenol phosphate as a new precursor for the modular regioselective synthesis of substituted furans

Owing to its importance in various realms of chemistry, furan occupies a position of eminence among heterocycles. Despite the availability of many methodologies for the synthesis of variably substituted furans, a modular convenient synthesis of 2,4-disubstituted furans remains challenging. The present work attempts to bridge that gap through a novel annulation-based approach using feedstock chemicals such as methyl ketones and their easily available derivatives, β-bromoenol phosphates. We have demonstrated a hitherto unknown reactivity of β-bromoenol phosphates which is responsible for the observed regioselectivity. The reaction requires only sodium hydride as the base under mild conditions. The scope of the reaction was found to be broad with the possibility of obtaining even tri-substituted furans besides a variety of 2,4-disubstituted furans. The methodology was applied to obtain synthetically challenging 3-acylfuran derivatives as well. The newly developed methodology is characterized by the modularity, regioselectivity as well as its practicality owing to easily available starting materials and fast reaction times.

Oxidative cross-coupling of allenyl ketones and organoboronic acids: Expeditious synthesis of highly substituted furans

Allenyl ketones are employed as coupling partners in palladium-catalyzed oxidative cross-coupling reactions with organoboronic acids. This reaction constitutes an efficient methodology for the synthesis of highly substituted furan derivatives. Palladium-carbene migratory insertion is proposed as the key step in this transformation. Migration patterns: Allenyl ketones are employed as a coupling partner in a palladium-catalyzed oxidative cross-coupling reaction with organoboronic acids. This reaction constitutes an efficient methodology for the synthesis of highly substituted furan derivatives. Palladium-carbene migratory insertion is proposed as the key step in this transformation. BQ=1,4-benzoquinone.