344396-18-5Relevant articles and documents
Industrial preparation method of 3,5-dimethoxy-4-alkylbenzyl alcohol
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Paragraph 0005; 0025, (2021/05/29)
The invention discloses an industrial preparation method of 3,5-dimethoxy-4-alkylbenzyl alcohol, belonging to the technical field of organic synthesis. According to the method, isopropyl chloride or isopropyl alcohol p-toluenesulfonate is selected, and isopropyl alcohol p-toluenesulfonate is directly subjected to Friedel-Crafts alkylation under the action of triethylamine hydrochloride ionic liquid serving as both a solvent and a catalyst; after the above reaction is finished, an organic solvent, such as methyl tert-butyl ether, is used for direct extraction and liquid separation, and the ionic liquid can be used repeatedly; sodium borohydride is directly used for reducing acyl imidazole obtained by subjecting isopropyl ester obtained in the previous stepto exchanging with imidazole in an aqueous tetrahydrofuran solution mildly (under the condition of 0-30 DEG C and without adding a catalyst); and after reduction is completed, a reduction product is directly poured into strong alkali solution with a concentration of 1-6 mol/L for quenching, and an organic phase is separated, so the 3,5-dimethoxy-4-alkylbenzyl alcohol is obtained safely and environmentally. The method is convenient and safe to operate, greatly reduces the problem of environmental pollution, and is suitable for industrial production.
Anti-inflammatory compound and application thereof
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, (2020/06/17)
The invention relates to the technical field of chemical cosmetics or medicines, and concretely relates to an anti-inflammatory compound and an application thereof. By preparing a series of compoundswith an anti-inflammatory function, the obtained anti-inflammatory compound can be used for preparing cosmetic reagents or pharmaceutical reagents, and the cosmetic reagents and the pharmaceutical reagents are not specifically limited, for example, the cosmetics can be a smoothing toner, a nutritional toner, a massage cream, a nutritional cream, a mask, an emollient, a gel, and gel or shower gel shampoo and other washing type cosmetics, and can also be a pharmaceutical preparation product similar to lotion and cream, ointment, cream, plaster or spray and the like. The anti-inflammatory compound also can be used by sensitive skins, and also can be added into infant and child cosmetics to reduce irritation.
Synthesis of a Benvitimod impurity: (Z)-3,5-dihydroxy-4-isopropylstilbene
Zhang, Yue,Du, Man,Xie, Hong-Wei,Song, Hai-Wen,Song, Yong-Xing,Qu, Hong-Ying,Yang, Ji-Xia
, p. 154 - 158 (2015/06/02)
(E)-3,5-dihydroxy-4-isopropylstilbene (Benvitimod), a new medicine for the treatment of psoriasis and eczema, belongs to the hydroxystilbene family. The synthesis leads to the E-isomer, (Z)-3,5-dihydroxy-4-isopropylstilbene being present as a major impuri