344407-17-6Relevant articles and documents
Effect of catalytic alkali metal bromide on Hofmann-type rearrangement of imides
Moriyama, Katsuhiko,Ishida, Kazuma,Togo, Hideo
supporting information; experimental part, p. 8574 - 8576 (2012/09/07)
The Hofmann-type rearrangement of aromatic and aliphatic imides using KBr as the catalyst proceeded to provide aromatic and aliphatic amino acid derivatives. We have also developed a new synthetic route to gabapentin with this method.
Electroorganic Chemistry. 82. β-Amino Acid Esters from α-Methoxycarbamates and Ketene Silyl Acetals; Cyclization to β-Lactams
Shono, Tatsuya,Tsubata, Kenji,Okinaga, Nobuyuki
, p. 1056 - 1059 (2007/10/02)
A new synthetic method of β-lactams 1'is described.The key intermediates, N-carbomethoxy-β-amino acid esters 2', were synthesized by the reaction of α-methoxylated carbamates 3' with ketene methyl trimethylsilyl acetals 4' catalyzed by titanium tetrachlor