344408-31-7

Basic information

• Product Name: 3-Bromo-3-(3-bromo-phenyl)-propionic acid
• Synonyms: 3-Bromo-3-(3-bromo-phenyl)-propionic acid
• CAS NO: 344408-31-7
• Molecular Weight: 307.969
• Mol File: 344408-31-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-Bromo-3-(3-bromo-phenyl)-propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-3-(3-bromo-phenyl)-propionic acid(344408-31-7)
• EPA Substance Registry System: 3-Bromo-3-(3-bromo-phenyl)-propionic acid(344408-31-7)

Safety Data

• Hazardous Substances Data: 344408-31-7(Hazardous Substances Data)

Upstream product

• 14473-91-7 3-Bromocinnamic acid 

Downstream Products

• 337964-57-5 4-bromo-4-(3-bromo-phenyl)-1-diazo-butan-2-one 

Relevant articles and documents

Ring expansion-annulation strategy for the synthesis of substituted azulenes and oligoazulenes. 2. Synthesis of azulenyl halides, sulfonates, and azulenylmetal compounds and their application in transition-metal-mediated coupling reactions

A "ring expansion-annulation strategy" for the synthesis of substituted azulenes is described based on the reaction of β'-bromo- α-diazo ketones with rhodium carboxylates. The key transformation involves an intramolecular Buechner reaction followed by β-elimination of bromide, tautomerization, and in situ trapping of the resulting 1-hydroxyazulene as a carboxylate or triflate ester. Further synthetic elaboration of the azulenyl halide and sulfonate annulation products can be achieved by employing Heck, Negishi, Stille, and Suzuki coupling reactions. Reaction of the azulenyl triflate 84 with pinacolborane provides access to the azulenylboronate 91, which participates in Suzuki coupling reactions with alkenyl and aryl iodides. The application of these coupling reactions to the synthesis of biazulenes, terazulene 101, and related oligoazulenes is described, as well as the preparation of the azulenyl amino acid derivative 110.

A CONTRIBUTION TO MECHANISM OF ADDITION OF HYDROGEN BROMIDE TO THE α,β-UNSATURATEDSYSTEM OF 3-PHENYL-2-PROPENOIC ACID

Rate of addition of hydrogen bromide to meta- and para-substituted 3-phenyl-2-propenoic acids I was followed by polarography and UV spectroscopy.Rate of protonation either is the overall rate determining step or is at least comparable with the rate of the subsequent nucleophile attack.