344798-32-9 Usage
Description
(6S)-6-[[tert-ButyldiMethylsilyloxy]-1,3,4,5,6,7-hexahydro-1-[(E)-[(1R,3aS,7aR)-octahydro-1-[(1S)-2-iodo-1-Methylethyl]-7a-Methyl-4H-inden-4-ylidene]Methyl]benzo[c]thiophene 2,2-Dioxide is a complex organic compound with a unique molecular structure. It is characterized by its hexahydro-1-[(E)-[(1R,3aS,7aR)-octahydro-1-[(1S)-2-iodo-1-Methylethyl]-7a-Methyl-4H-inden-4-ylidene]Methyl]benzo[c]thiophene 2,2-Dioxide core, which is modified with a tert-ButyldiMethylsilyloxy group. (6S)-6-[[tert-ButyldiMethylsilyloxy]-1,3,4,5,6,7-hexahydro-1-[(E)-[(1R,3aS,7aR)-octahydro-1-[(1S)-2-iodo-1-Methylethyl]-7a-Methyl-4H-inden-4-ylidene]Methyl]benzo[c]thiophene 2,2-Dioxide is an intermediate in the synthesis of Secalciferol (S211500), a metabolite of Vitamin D with potential anti-inflammatory properties.
Uses
Used in Pharmaceutical Industry:
(6S)-6-[[tert-ButyldiMethylsilyloxy]-1,3,4,5,6,7-hexahydro-1-[(E)-[(1R,3aS,7aR)-octahydro-1-[(1S)-2-iodo-1-Methylethyl]-7a-Methyl-4H-inden-4-ylidene]Methyl]benzo[c]thiophene 2,2-Dioxide is used as an intermediate in the synthesis of Secalciferol (S211500), a metabolite of Vitamin D. Secalciferol has potential anti-inflammatory properties, making it a valuable compound in the development of new pharmaceuticals for the treatment of various inflammatory conditions.
Used in Vitamin D Research:
As an intermediate in the synthesis of Secalciferol, (6S)-6-[[tert-ButyldiMethylsilyloxy]-1,3,4,5,6,7-hexahydro-1-[(E)-[(1R,3aS,7aR)-octahydro-1-[(1S)-2-iodo-1-Methylethyl]-7a-Methyl-4H-inden-4-ylidene]Methyl]benzo[c]thiophene 2,2-Dioxide plays a crucial role in research related to Vitamin D and its metabolites. (6S)-6-[[tert-ButyldiMethylsilyloxy]-1,3,4,5,6,7-hexahydro-1-[(E)-[(1R,3aS,7aR)-octahydro-1-[(1S)-2-iodo-1-Methylethyl]-7a-Methyl-4H-inden-4-ylidene]Methyl]benzo[c]thiophene 2,2-Dioxide can be used to study the biological activities and potential therapeutic applications of Secalciferol and other Vitamin D-related compounds.
Used in Chemical Synthesis:
Due to its complex molecular structure, (6S)-6-[[tert-ButyldiMethylsilyloxy]-1,3,4,5,6,7-hexahydro-1-[(E)-[(1R,3aS,7aR)-octahydro-1-[(1S)-2-iodo-1-Methylethyl]-7a-Methyl-4H-inden-4-ylidene]Methyl]benzo[c]thiophene 2,2-Dioxide can also be used as a building block or starting material in the synthesis of other complex organic compounds. This makes it a valuable tool for chemists working in various fields, including materials science, pharmaceuticals, and agrochemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 344798-32-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,4,7,9 and 8 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 344798-32:
(8*3)+(7*4)+(6*4)+(5*7)+(4*9)+(3*8)+(2*3)+(1*2)=179
179 % 10 = 9
So 344798-32-9 is a valid CAS Registry Number.
344798-32-9Relevant articles and documents
A stereospecific synthesis of 24(S)-hydroxyvitamin D2, a prodrug for 1α,24(S)-dihydroxyvitamin D2
Coutts, Lisa D.,Geiss, William B.,Gregg, Brian T.,Helle, Mark A.,King, Chi-Hsin R.,Itov, Zinovy,Mateo, Mary E.,Meckler, Harold,Zettler, Mark W.,Knutson, Joyce C.
, p. 246 - 255 (2013/09/06)
This contribution describes the first stereospecific synthesis of 24(S)-hydroxyvitamin D2 (1), a metabolite of vitamin D2. This metabolite acts as a prodrug for 1α,24(S)-dihydroxyvitamin D2 (2), which is under development for treatment of various diseases characterized by cellular hyperproliferation. The key step of the synthesis involves the Wittig-Horner olefination of (S)-2,3-dimethyl-2-triethysilyloxybutyraldehyde (17) and a vitamin D2 phosphine oxide derivative (22). The synthesis of the requisite aldehyde started with the commercially available L-(+)-valine and was completed in seven steps. The vitamin D2 phosphine oxide derivative was synthesized in seven steps starting from vitamin D2.
