34497-13-7

Basic information

• Product Name: 2-butyl-1-oxo-3-phenyl-1,2-dihydroisoquinoline
• Synonyms: 2-butyl-1-oxo-3-phenyl-1,2-dihydroisoquinoline
• CAS NO: 34497-13-7
• Molecular Weight: 277.366
• Mol File: 34497-13-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-butyl-1-oxo-3-phenyl-1,2-dihydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-butyl-1-oxo-3-phenyl-1,2-dihydroisoquinoline(34497-13-7)
• EPA Substance Registry System: 2-butyl-1-oxo-3-phenyl-1,2-dihydroisoquinoline(34497-13-7)

Safety Data

• Hazardous Substances Data: 34497-13-7(Hazardous Substances Data)

Upstream product

• 5955-73-7 2-methylbenzoyl cyanide 
• 349403-39-0 N-butyl 2-bromobenzamide 
• 98-86-2 acetophenone 
• 213599-19-0 1-bromo-2-(2,2-dibromovinyl)benzene 
• 6630-33-7 ortho-bromobenzaldehyde 
• 1333307-42-8 (Z)-1-bromo-2-(2-bromo-2-phenylethenyl)benzene 
• 201230-82-2 carbon monoxide 
• 933-88-0 ortho-toluoyl chloride 
• 613-90-1 benzoyl cyanide 
• 111-36-4 n-butyl isocyanide 
• 21375-88-2 1-bromo-2-(phenylethenyl)benzene 
• 146439-70-5 3,4-dihydro-3-cyano-3-phenyl-1H-2-benzopyran-1-one 
• 109-73-9 N-butylamine 

Relevant articles and documents

Synthesis of functionalized isoquinolin-1(2H)-ones by copper-catalyzed α-arylation of ketones with 2-halobenzamides

Copper is key: A concise route to isoquinolin-1(2H)-ones from simple and readily available starting materials is provided by an efficient copper-catalyzed annulation of ketones with 2-halobenzamides. The method is applicable to a wide range of ketones con

Method of catalyzing tandem reaction to synthesize isoquinolinone derivative in water phase

The invention provides a method of catalyzing tandem reaction to synthesize isoquinolinone derivative in water phase. In the method, the isoquinolinone derivative is synthesized in a one-pot manner that on the basis of 1 mol of 0.1-1 mol/L ortho-halogenated benzamide and 0.1-5 mol of a terminal alkyne, a reaction is carried out in a water phase under the effect of 0.001-1 mol of bivalent copper salt and phenanthroline catalysts in the presence of 0.5-6 mol of inorganic alkali or organic alkali, reaction temperature being 20-160 DEG C and reaction time being 1-50 h. In the method, the bivalent copper salt and phenanthroline can catalyze the reaction between the ortho-halogenated benzamide and the terminal alkyne in the water phase, wherein water serves as a solvent, so that the method is environment-friendly, and avoids usage of noble metals, high temperature reaction and the like reaction conditions. The method has simple operations and high yield, is safe and low-cost, is low in pollution and is suitable for various functional groups.

Acyl cyanides as carbonyl heterodienophiles: Application to the synthesis off naphthols, isoquinolones, and isocoumarins

Irradiation of 2-methylbenzoyl cyanide (3a) in acetonitrile solution results in the formation of its dimer, which upon loss of HCN gives rise to the cycloadduct 7a. The dimerization also proceeds efficiently with derivatives of 3a giving adducts 7b and 7c