3450-65-5Relevant articles and documents
A process for preparing β - carbonyl phosphine ester method
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Paragraph 0078; 0079; 0080; 0081; 0082; 0083, (2017/07/31)
The invention discloses a method for synthesizing beta-carboxyl phosphate from alkyne or alkynyl carboxylic compounds and phosphite ester in the presence of copper/iron salt serving as catalysts and molecular oxygen serving as an oxidant. According to the method, multifunctional beta-carboxyl phosphate is obtained by virtue of a novel method having wide substrate range in the presence of the inexpensive catalysts (copper salts and iron salts) in oxygen, which is in a sharp contrast with previously reported view that alkyne cannot act in the presence of molecular oxygen. The method disclosed by the invention has the advantages of mild reaction conditions, easily available raw materials, good compatibility with various reactants, strong practicality and high yield and can be widely applied to various functional reactions.
Acylation of diethyl phosphonoacetic acid via the MgCl2/Et3N system: A practical synthesis of β-keto phosphonates
Corbel, Bernard,L'Hostis-Kervella, Isabelle,Haelters, Jean-Pierre
, p. 609 - 618 (2007/10/03)
A one pot simple procedure for the synthesis of β-keto phosphonates has been developed using the MgCl2/Et3N base system to generate the magnesium enolate of diethyl phosphonoacetic acid. This intermediate reacts with acid chlorides or imidazolides to give, after workup, the title compounds in good yields.
Acylation of in situ generated trimethylsilyl diethylphosphonoacetate using magnesium chloride-triethylamine: a practical synthesis of β-keto phosphonates
Kim, Dae Young,Kong, Myeon Sik,Lee, Kilsung
, p. 1360 - 1364 (2007/10/03)
In situ generated trimethylsilyl diethylphosphonoacetate from diethyl phosphonoacetic acid can be acylated with carboxylic acid chlorides in the presence of magnesium chloride to prepare a variety of β-keto phosphonates.This synthetic methods is suitable for the preparation of β-keto phosphonates in the laboratory and also for large-scale production.