345217-88-1Relevant articles and documents
Stereoselective glycosylation of 2-nitrogalactals catalyzed by a bifunctional organocatalyst
Medina, Sandra,Harper, Matthew J.,Balmond, Edward I.,Miranda, Silvia,Crisenza, Giacomo E. M.,Coe, Diane M.,McGarrigle, Eoghan M.,Galan, M. Carmen
, p. 4222 - 4225 (2016)
The use of a bifunctional cinchona/thiourea organocatalyst for the direct and α-stereoselective glycosylation of 2-nitrogalactals is demonstrated for the first time. The conditions are mild, practical, and applicable to a wide range of glycoside acceptors with products being isolated in good to excellent yields. The method is exemplified in the synthesis of mucin type Core 6 and 7 glycopeptides.
Enantioselective Organocatalyzed Direct α-Thiocyanation of Cyclic β-Ketoesters by N -Thiocyanatophthalimide
Qiu, Jiashen,Wu, Di,Karmaker, Pran Gopal,Yin, Hongquan,Chen, Fu-Xue
supporting information, p. 1600 - 1603 (2018/03/23)
A new electrophilic thiocyanation reagent, N-thiocyanatophthalimide, was synthesized and applied to the first example of catalytic asymmetric electrophilic α-thiocyanation of various cyclic β-ketoesters by the bifunctional cinchona alkaloid catalysis. Thus, a variety of chiral α-thiocyanato β-ketoesters with a quaternary carbon center have been achieved in excellent yields (up to 99%) and high enantioselectivities (up to 94% ee) in a convenient manner.
