345223-69-0

Basic information

• Product Name: 7-(2-benzyloxy-ethyl)-3,4,4a,5,6,8a-hexahydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester
• Synonyms: 7-(2-benzyloxy-ethyl)-3,4,4a,5,6,8a-hexahydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester
• CAS NO: 345223-69-0
• Molecular Weight: 371.52
• Mol File: 345223-69-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-(2-benzyloxy-ethyl)-3,4,4a,5,6,8a-hexahydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(2-benzyloxy-ethyl)-3,4,4a,5,6,8a-hexahydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester(345223-69-0)
• EPA Substance Registry System: 7-(2-benzyloxy-ethyl)-3,4,4a,5,6,8a-hexahydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester(345223-69-0)

Safety Data

• Hazardous Substances Data: 345223-69-0(Hazardous Substances Data)

Upstream product

• 84-31-1 quininone 
• 345223-81-6 (3R,4S)-4-(2-isopropoxy-2-oxoethyl)-3-vinylpiperidine-1-carboxylic acid t-butyl ester 
• 345223-66-7 (3R,4R)-4-But-3-ynyl-3-vinyl-piperidine-1-carboxylic acid tert-butyl ester 
• 345223-67-8 7-vinyl-3,4,4a,5,6,8a-hexahydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 345223-65-6 tert-butyl (3R,4S)-4-(2-hydroxyethyl)-3-vinylpiperidine-1-carboxylate 
• 345223-64-5 isopropyl 2-((3R,4S)-3-vinylpiperidin-4-yl)acetate 
• 130-95-0 quinine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 100-39-0 benzyl bromide 
• 345223-82-7 7-(2-hydroxy-ethyl)-3,4,4a,5,6,8a-hexahydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 

Relevant articles and documents

A concise enantioselective synthesis of the AB ring system of the manzamine alkaloids by ring-closing enyne metathesis

The AB ring system found in the manzamine A and related alkaloids has been prepared from (-)-quinine by a short enantioselective route. The key step in the sequence is a ruthenium-catalysed ring-closing enyne metathesis re action which delivers a bicyclic diene in good yield. The functionality required for further elaboration of the AB system has been installed by sequential regioselective hydroboration and stereoselective catalytic aminohydroxylation.