34551-44-5

Basic information

• Product Name: N-(4-vinylphenyl)formamide
• Synonyms: N-(4-vinylphenyl)formamide
• CAS NO: 34551-44-5
• Molecular Weight: 147.177
• Mol File: 34551-44-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: N-(4-vinylphenyl)formamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-vinylphenyl)formamide(34551-44-5)
• EPA Substance Registry System: N-(4-vinylphenyl)formamide(34551-44-5)

Safety Data

• Hazardous Substances Data: 34551-44-5(Hazardous Substances Data)

Upstream product

• 1520-21-4 4-vinyl benzylamine 
• 77287-34-4 formamide 
• 109-94-4 formic acid ethyl ester 
• 2258-42-6 formyl acetic anhydride 
• 124-38-9 carbon dioxide 
• 99-92-3 p-aminobenzophenone 

Downstream Products

• 34325-86-5 4-vinyl-1-isocyanobenzene 
• 1201360-71-5 2-[(4-{[(2-methoxy-1-methylethyl)amino]methyl}phenyl)amino]-5,5-dimethyl-7-[(1S)-1-methylpropyl]-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one 
• 1201362-92-6 5,5-dimethyl-7-[(1S)-1-methylpropyl]-2-[(4-vinylphenyl)amino]-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one 
• 1201362-94-8 4-({5,5-dimethyl-7-[(1S)-1-methylpropyl]-6-oxo-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-2-yl}amino)benzaldehyde 

Relevant articles and documents

Direct Synthesis of Unprotected 2-Azidoamines from Alkenes via an Iron-Catalyzed Difunctionalization Reaction

Unprotected, primary 2-azidoamines are versatile precursors to vicinal diamines, which are among the most common motifs in biologically active compounds. Herein, we report their operationally simple synthesis through an iron-catalyzed difunctionalization of alkenes. A wide array of alkene substrates are tolerated, including complex drug-like molecules and a tripeptide. Facile derivatizations of the azidoamine group demonstrate the versatility of this masked diamine motif in chemoselective, orthogonal transformations. Applications of the methodology in the concise synthesis of RO 20-1724 as well as in the formal total syntheses of both (±)-hamacanthin B and (±)-quinagolide further demonstrate the broad synthetic potential of this highly functional-group-tolerant reaction.

Novel method for synthesizing N-substitute amide derivative

The invention discloses a novel method for synthesizing an N-substitute amide derivative. The novel method is characterized by comprising the steps that at the air atmosphere, no catalyst or alkali or other any additives are added, an organic amine compound shown in a formula (I) is adopted as a reaction substrate, a solvent shown in a formula (II) is adopted as an acylation reagent, an acylation reaction is performed under the reaction temperature of 120-150 DEG C to generate the N-substitute amide derivative shown in a formula (III), and the equation is shown in the description. The novel method has the advantages that environmental protection is achieved, and post-treatment and product separation are easy; the range of the substrate is wide, and the substrate can be primary amine and can also be secondary amine; the solvent can be amide and can also be carboxylic acid, and the solvent can be adopted as the acylation reagent to participate in the reaction; the reaction efficiency is high, and the majority of reactions can reach the quantified yield; water and air have no effect on the reaction, inert gas shielding is not needed, and operation is easy.

5,7-DIHYDRO-6H-PYRROLO[2,3-D]PYRIMIDIN-6-ONE DERIVATIVES FOR MARK INHIBITION

Compounds of formula I: are potent and selective inhibitors of microtubule affinity regulating kinase (MARK), and hence find use in treatment of Alzheimer's disease and other conditions associated with hyperphosphorylation of tau.