345642-90-2

Basic information

• Product Name: 2-(DIMETHYLAMINO)-4,6-DIMETHYLPYRIMIDIN-5-OL
• Synonyms: 2-(DIMETHYLAMINO)-4,6-DIMETHYLPYRIMIDIN-5-OL
• CAS NO: 345642-90-2
• Molecular Formula: C8H13N3O
• Molecular Weight: 167.21
• Mol File: 345642-90-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(DIMETHYLAMINO)-4,6-DIMETHYLPYRIMIDIN-5-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(DIMETHYLAMINO)-4,6-DIMETHYLPYRIMIDIN-5-OL(345642-90-2)
• EPA Substance Registry System: 2-(DIMETHYLAMINO)-4,6-DIMETHYLPYRIMIDIN-5-OL(345642-90-2)

Safety Data

• Hazardous Substances Data: 345642-90-2(Hazardous Substances Data)

Usage

General Description

2-(dimethylamino)-4,6-dimethylpyrimidin-5-ol is a chemical compound with a molecular formula C9H14N2O. It is a pyrimidine derivative and a member of the drug class known as antineoplastic agents. The compound has been studied for its potential anticancer properties and is being researched as a possible treatment for various types of cancer. It is believed to work by interrupting the processes of cell division and growth, leading to the inhibition of cancerous tumor growth. However, further research and clinical trials are needed to fully understand the effectiveness and safety of this compound as a cancer treatment.

Upstream product

• 311-77-3 1,1-dimethylguanidine dihydrogensulfate 
• 18632-38-7 3-acetoxypentane-2,4-dione 
• 50-00-0 formaldehyd 
• 685897-68-1 2-amino-4,6-dimethyl-5-pyrimidinol 
• 1694-29-7 3-chloropentane-2,4-dione 
• 1083329-39-8 5-benzyloxy-4,6-dimethyl-2-N,N-dimethylaminopyrimidine 
• 78-98-8 2-oxopropanal 
• 627098-10-6 5-bromo-4,6-dimethyl-2-(dimethylamino)pyridine 

Relevant articles and documents

Peroxyl radical clocks

A series of peroxyl radical clocks has been developed and calibrated based on the competition between the unimolecular β-fragmentation (k β) of a peroxyl radical and its bimolecular reaction with a hydrogen atom donor (kH). These clocks are based on either methyl linoleate or allylbenzene and were calibrated directly with α-tocopherol or methyl linoleate, which have well-established rate constants for reaction with peroxyl radicals (kH-tocopherol = 3.5 × 10-6 M-1 s-1, kH-linoieate = 62 M-1 s-1). This peroxyl radical clock methodology has been successfully applied to determine inhibition and propagation rate constants ranging from 10° to 107 M-1 s-1.

An expeditious access to 5-pyrimidinol derivatives from cyclic methylglyoxal diadducts, formation of argpyrimidines under physiological conditions and discovery of new CFTR inhibitors

In the study of previously reported modulators of CFTR chloride channels that are cyclic methylglyoxal (MG) diadducts (CMGD) to aromatic α-aminoazaheterocycles, we optimized a new expeditious one pot route for preparing in water novel aromatic polycyclic azaheterocycles and described 5-pyrimidinols antioxidants through the formation of 2-oxoaldehyde diadducts to aromatic α-aminoazaheterocycles, amidines, guanidines and thiourea. In regard to the importance as biomarkers of diabetic complications of the 5-pyrimidinols "argpyrimidines" formed in proteins from MG and arginine residues, we demonstrated that argpyrimidines are slowly formed under physiological conditions from CMGD to arginine derivatives according to the synthesis route described. Among the 5-pyrimidinol derivatives prepared, two polycyclic derivatives appeared to inhibit strongly the activity of CFTR channels in wt-CHO cells.

The Effect of Ring Nitrogen Atoms on the Homolytic Reactivity of Phenolic Compounds: Understanding the Radical-Scavenging Ability of 5-Pyrimidinols

Six substituted 5-pyrimidinols were synthesized, and the thermochemistry and kinetics of their reactions with free radicals were studied and compared to those of equivalently substituted phenols. To assess their potential as hydrogen-atom donors to free r