34576-15-3

Basic information

• Product Name: N-(4-nitro-benzoyl)-DL-leucine methyl ester
• CAS NO: 34576-15-3
• Molecular Weight: 294.307
• Mol File: 34576-15-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(4-nitro-benzoyl)-DL-leucine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-nitro-benzoyl)-DL-leucine methyl ester(34576-15-3)
• EPA Substance Registry System: N-(4-nitro-benzoyl)-DL-leucine methyl ester(34576-15-3)

Safety Data

• Hazardous Substances Data: 34576-15-3(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 65952-92-3 4-methyl-2-(4-nitrobenzamido)-pentanoic acid 
• 61-90-5 L-leucine 
• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 122-04-3 4-nitro-benzoyl chloride 
• 62-23-7 4-nitro-benzoic acid 
• 110-86-1 pyridine 
• 2666-93-5 (S)-Leu-OMe 

Downstream Products

• 1403587-95-0 N-(1-(2-cyano-1,2-dimethylhydrazinyl)-4-methyl-1-oxopentan-2-yl)-4-nitrobenzamide 
• 100759-29-3 N-(4-nitro-benzoyl)-L-leucine 

Relevant articles and documents

Highly selective azadipeptide nitrile inhibitors for cathepsin K: Design, synthesis and activity assays

We have developed a series of azadipeptide nitriles with different P3 groups. A triaryl meta-phenyl derivative, compound 13, was not only a potent inhibitor for cathepsin K (Ki = 0.0031 nM), but also highly selective over both cathepsins B and S (～1000-fold). A protein-ligand docking study performed on the series provided a possible explanation why compound 13 could be significantly more potent than the others, especially compound 12 in the same series.