345915-09-5Relevant articles and documents
Application of an enantiomerically pure bicyclic thiolactone in the synthesis of a farnesyl transferase inhibitor
Abbas, Sahar,Ferris, Leigh,Norton, Alison K.,Powell, Lyn,Robinson, Graham E.,Siedlecki, Paul,Southworth, Rebecca J.,Stark, Andrew,Williams, Emyr G.
, p. 202 - 212 (2013/01/03)
An efficient manufacturing route to a novel farnesyl transferase inhibitor is described. The target molecule is a pro-drug, and its synthesis is complicated by the presence of labile functionality. The Medicinal Chemistry synthesis required trityl mercapt