345987-15-7 Usage
Description
AS601245, also known as Glycerol, is a simple polyol compound that is widely used in various industries due to its unique properties. It is a colorless, odorless, and viscous liquid with a sweet taste. Glycerol is hygroscopic, meaning it can absorb moisture from the air, and it is also a versatile solvent for various substances. Its hydroxyl groups allow it to form hydrogen bonds with other molecules, making it a valuable component in many applications.
Uses
Used in Pharmaceutical Industry:
AS601245 is used as an anti-inflammatory JNK inhibitor for its neuroprotective properties. It plays a crucial role in the treatment of various inflammatory conditions and neurological disorders by inhibiting the activation of the c-Jun N-terminal kinase (JNK) pathway, which is involved in the regulation of cell survival, apoptosis, and inflammation.
Used in Cancer Research:
In the field of cancer research, AS601245 is used as a JNK inhibitor to study the role of JNK in cancer cell proliferation, apoptosis, and differentiation. It helps researchers understand the molecular mechanisms underlying cancer development and progression, which can lead to the discovery of novel therapeutic strategies.
Used in Drug Delivery Systems:
AS601245 is used as a component in drug delivery systems to improve the solubility, stability, and bioavailability of various drugs. Its ability to form hydrogen bonds with other molecules makes it an ideal candidate for encapsulating and delivering drugs, particularly those with poor water solubility.
Used in Cosmetics Industry:
In the cosmetics industry, AS601245 is used as a humectant to help retain moisture in the skin, keeping it hydrated and healthy. Its hygroscopic nature makes it an effective ingredient in various skincare products, such as lotions, creams, and moisturizers.
Used in Food Industry:
In the food industry, AS601245 is used as a humectant, emulsifier, and sweetener. It helps maintain the moisture content in foods, preventing them from becoming too dry or hard. It is also used to improve the texture and stability of various food products, such as baked goods, confectionery, and beverages.
Used in Personal Care Products:
AS601245 is used in personal care products, such as toothpaste, mouthwashes, and shaving creams, due to its humectant and moisturizing properties. It helps maintain the moisture balance in the oral cavity and on the skin, providing a soothing and comforting effect.
Used in Industrial Applications:
In industrial applications, AS601245 is used as a solvent, lubricant, and antifreeze due to its low freezing point and ability to dissolve a wide range of substances. It is also used in the production of various chemicals, such as glycerol esters, glycerol ethers, and polyglycerols, which have applications in the manufacturing of resins, plastics, and other materials.
Biological Activity
recent evidence suggests activation of the c-jun nh2-terminal protein kinase (jnk) signal transduction pathway may play a role in ischemia-induced cell death. therefore, preventing the activation of jnk, or c-jun phosphorylation could be neuroprotective. as601245 is a c-jun nh2-terminal protein kinase inhibitor.
in vitro
as601245 demonstrated a nonspecific inhibition of the three jnk human isoforms. as601245 inhibits isolated hjnk3 in an atpcompetitive manner. selectivity of as601245 was tested against a large panel of kinases. it exhibited 10- to 20-fold selectivity over c-src, cdk2, and c-raf and more than 50- to 100-fold selectivity over a range of tyr- and ser/thr-protein kinases [1].
in vivo
as601245 administered i.p. provided significant protection against the delayed loss of hippocampal ca1 neurons in a gerbil model of transient global ischemia. this effect is mediated by jnk inhibition and thus by c-jun expression and phosphorylation. a significant neuroprotective effect of as601245 administered either by i.p. injection or as i.v. bolus followed by an i.v. infusion was also observed in rats after focal cerebral ischemia [1].
IC 50
150, 220, and 70 nm for hjnk1, hjnk2, and hjnk3, respectively
references
[1] carboni s, hiver a, szyndralewiez c, gaillard p, gotteland jp, vitte pa. as601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-jun nh2-terminal protein kinase inhibitor with neuroprotective properties. j pharmacol exp ther. 2004 jul;310(1):25-32. epub 2004 feb 26.
Check Digit Verification of cas no
The CAS Registry Mumber 345987-15-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,5,9,8 and 7 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 345987-15:
(8*3)+(7*4)+(6*5)+(5*9)+(4*8)+(3*7)+(2*1)+(1*5)=187
187 % 10 = 7
So 345987-15-7 is a valid CAS Registry Number.
InChI:InChI=1/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,25H,7,10H2,(H,23,24,26)/b19-15-
