34599-62-7

Basic information

• Product Name: ethyl 2-ethoxycarbonyl-3-methyl-4-phenylbutanoate
• CAS NO: 34599-62-7
• Molecular Weight: 278.348
• Mol File: 34599-62-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: ethyl 2-ethoxycarbonyl-3-methyl-4-phenylbutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-ethoxycarbonyl-3-methyl-4-phenylbutanoate(34599-62-7)
• EPA Substance Registry System: ethyl 2-ethoxycarbonyl-3-methyl-4-phenylbutanoate(34599-62-7)

Safety Data

• Hazardous Substances Data: 34599-62-7(Hazardous Substances Data)

Upstream product

• 996-82-7 sodium diethylmalonate 
• 1459-00-3 1-bromo-2-phenylpropane 
• 873-66-5 1-propenylbenzene 
• 1462-12-0 diethyl ethylidenemalonate 
• 60-12-8 2-phenylethanol 
• 300-57-2 allylbenzene 

Downstream Products

• 34599-77-4 (E)-1-methyl-2-(penta-2,4-dien-2-yl)benzene 
• 34599-78-5 1-Methyl-2-((Z)-1-methyl-buta-1,3-dienyl)-benzene 
• 3344-45-4 3-methyl-1,2,3,4-tetrahydro-1-naphthol 
• 14944-23-1 3-methyl-1-tetralone 

Relevant articles and documents

Dehydroxymethylation of Alcohols Enabled by Cerium Photocatalysis

Dehydroxymethylation, the direct conversion of alcohol feedstocks as alkyl synthons containing one less carbon atom, is an unconventional and underexplored strategy to exploit the ubiquity and robustness of alcohol materials. Under mild and redox-neutral reaction conditions, utilizing inexpensive cerium catalyst, the photocatalytic dehydroxymethylation platform has been furnished. Enabled by ligand-to-metal charge transfer catalysis, an alcohol functionality has been reliably transferred into nucleophilic radicals with the loss of one molecule of formaldehyde. Intriguingly, we found that the dehydroxymethylation process can be significantly promoted by the cerium catalyst, and the stabilization effect of the fragmented radicals also plays a significant role. This operationally simple protocol has enabled the direct utilization of primary alcohols as unconventional alkyl nucleophiles for radical-mediated 1,4-conjugate additions with Michael acceptors. A broad range of alcohols, from simple ethanol to complex nucleosides and steroids, have been successfully applied to this fragment coupling transformation. Furthermore, the modularity of this catalytic system has been demonstrated in diversified radical-mediated transformations including hydrogenation, amination, alkenylation, and oxidation.

170. Asymmetric Palladium-Assisted Alkylation of Alkenes

Palladium-promoted alkylation of alkenes using chiral sulfoxide-containing carbanions and chiral lithiated oxazolines results in asymmetric induction (AI) ranging from 3-5 percent (1,5 induction), 20-40 percent (1,3 induction) to 44-52 percent (1,4 induction).No general trend allowing predictions of results was found.With 1-hexene, attack at C(1) is almost exclusive but propene gives a mixture of attack at C(1) and C(2).The use of a chiral ligand together with malonate anion also leads to some asymmetric induction (ca. 20 percent).