346-43-0

Basic information

• Product Name: 4-FLUORO-2-NITRO-ALPHA-OXO-BENZENE PROPANOIC ACID ETHYL ESTER
• Synonyms: 4-FLUORO-2-NITRO-ALPHA-OXO-BENZENE PROPANOIC ACID ETHYL ESTER;Ethyl 3-(4-fluoro-2-nitrophenyl)-2-oxopropanoate
• CAS NO: 346-43-0
• Molecular Formula: C₁₁H₁₀FNO₅
• Molecular Weight: 255.1992032
• Mol File: 346-43-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-FLUORO-2-NITRO-ALPHA-OXO-BENZENE PROPANOIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORO-2-NITRO-ALPHA-OXO-BENZENE PROPANOIC ACID ETHYL ESTER(346-43-0)
• EPA Substance Registry System: 4-FLUORO-2-NITRO-ALPHA-OXO-BENZENE PROPANOIC ACID ETHYL ESTER(346-43-0)

Safety Data

• Hazardous Substances Data: 346-43-0(Hazardous Substances Data)

Upstream product

• 446-10-6 2-nitro-4-fluorotoluene 
• 95-92-1 oxalic acid diethyl ester 

Downstream Products

• 348-37-8 6-fluoro-1H-indole-2-carboxylic acid ethyl ester 

Relevant articles and documents

Preparation of optically enriched 3-hydroxy-3,4-dihydroquinolin-2(1H)-ones by heterogeneous catalytic cascade reaction over supported platinum catalyst

The development of a novel heterogeneous catalytic asymmetric cascade reaction for the synthesis of tetrahydroquinolines from 2-nitrophenylpyruvates is reported. Optically enriched 3-hydroxy-3,4-dihydroquinolin-2(1H)-ones are prepared by enantioselective hydrogenation of the activated keto group over a Cinchona alkaloid-modified Pt catalyst, reduction of the nitro group and spontaneous cyclization cascade. Acceleration of the enantioselective hydrogenation of the activated keto group over the catalyst modified by Cinchona alkaloids ensured high tetrahydroquinolinone selectivities. The scope of the reaction was checked using twelve substrates. Both yields and enantioselectivities were significantly influenced by the nature and position of the substituents on the phenyl ring. Substituents adjacent to the nitro group considerably increased the product yield, due to their effect on the nitro group′s reduction rate; however, had only a limited effect on enantioselectivities. Copyright

SUBSTITUTED INDOLE COMPOUND

Disclosed is an excellent LXR modulator. A compound represented by the general formula (I): (I) wherein R1, R2, R3 and R4: H, an alkyl which may be substituted, OH, an alkoxy which may be substituted, an amino which may be substituted, a halogeno, a phenyl or the like; R5: H or an alkyl; R6: -COR8 (wherein R8: an alkoxy which may be substituted, a phenyloxy which may be substituted, an amino which may be substituted, or the like), -SO2R9 (wherein R9: an alkyl which may be substituted, a phenyl which may be substituted or a heterocyclyl which may be substituted), or an alkyl which may be substituted; R7: -X2R10 [wherein R10: -COR11 (where R11: OH, an alkoxy which may be substituted or an amino which may be substituted), -SO2R12 (where R12: an alkyl which may be substituted or amino which may be substituted), -N(R13)COR14 (where R13: H or an alkyl which may be substituted; R14: H or an alkyl which may be substituted), -N(R13)SO2R15 (where R13: as defined above; R15: an alkyl which may be substituted) or tetrazol-5-yl; and X2: a single bond or an alkylene which may be substituted]; X1: a methylene which may be substituted; Y1: a phenyl which may be substituted or a heterocyclyl which may be substituted; and Y2: an aryl which may be substituted, a heterocyclyl which may be substituted or the like], or the like.