34631-53-3

Basic information

• Product Name: 4-ethyl-1,3-thiazol-2-amine(SALTDATA: HCl 0.7H2O)
• Synonyms: 4-ethyl-1,3-thiazol-2-amine(SALTDATA: HCl 0.7H2O);4-ethyl-1,3-thiazol-2-aMine;2-Amino-4-ethylthiazole;4-Ethylthiazol-2-amine;4-ethylthiazol-2-amine hydrochloride
• CAS NO: 34631-53-3
• Molecular Formula: C₅H₈N₂S
• Molecular Weight: 164.65636
• Mol File: 34631-53-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 35 °C
• Boiling Point: 118-120 °C
• Appearance: /
• Density: 1.195±0.06 g/cm3(Predicted)
• PKA: 5.42±0.10(Predicted)
• CAS DataBase Reference: 4-ethyl-1,3-thiazol-2-amine(SALTDATA: HCl 0.7H2O)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ethyl-1,3-thiazol-2-amine(SALTDATA: HCl 0.7H2O)(34631-53-3)
• EPA Substance Registry System: 4-ethyl-1,3-thiazol-2-amine(SALTDATA: HCl 0.7H2O)(34631-53-3)

Safety Data

• Hazardous Substances Data: 34631-53-3(Hazardous Substances Data)

Usage

General Description

4-ethyl-1,3-thiazol-2-amine (SALTDATA: HCl 0.7H2O) is a chemical compound with the molecular formula C5H10ClN3OS and a molar mass of 190.67 g/mol. It consists of a thiazole ring with an ethyl group and an amine group attached to it. The compound is a salt form of the amine, containing hydrochloric acid and water as well. It is commonly used in organic synthesis and pharmaceutical research as a building block for various compounds. The presence of the salt and water in the compound may affect its solubility, stability, and other properties, making it important to consider in its application and handling.

Upstream product

• 64-17-5 ethanol 
• 616-27-3 1-chlorobutan-2-one 
• 17356-08-0 thiourea 
• 113647-42-0 3-Bromo-but-1-yne 
• 78-93-3 butanone 
• 262372-87-2 4-ethyl-1,3-thiazol-2-amine hydrobromide 
• 816-40-0 1-Bromo-2-butanone 

Downstream Products

• 87613-97-6 N-(4-ethyl-thiazol-2-yl)-benzamide 
• 34631-45-3 cyclohexyl-(4-ethyl-thiazol-2-yl)-amine 
• 149485-47-2 1-(4-Ethyl-thiazol-2-yl)-3-phenethyl-thiourea 
• 16630-43-6 sulfanilic acid-(4-ethyl-thiazol-2-ylamide) 
• 20158-33-2 benzaldehyde 4-(4-ethyl-thiazol-2-yl)-thiosemicarbazone 
• 20158-32-1 4-methyl-benzaldehyde 4-(4-ethyl-thiazol-2-yl)-thiosemicarbazone 
• 20158-34-3 4-methoxy-benzaldehyde 4-(4-ethyl-thiazol-2-yl)-thiosemicarbazone 
• 20158-31-0 4-dimethylamino-benzaldehyde 4-(4-ethyl-thiazol-2-yl)-thiosemicarbazone 
• 20517-80-0 [5-(4-dimethylamino-phenyl)-[1,3,4]thiadiazol-2-yl]-(4-ethyl-thiazol-2-yl)-amine 
• 34631-49-7 N-(5-tert-butyl-4-ethyl-thiazol-2-yl)-2-hydroxy-benzamide 
• 1158211-11-0 5-bromo-4-ethyl-thiazol-2-ylamine 
• 89322-56-5 2-bromo-4-ethyl-1,3-thiazole 

Relevant articles and documents

Optimization of Novel 1-Methyl-1 H-Pyrazole-5-carboxamides Leads to High Potency Larval Development Inhibitors of the Barber's Pole Worm

A phenotypic screen of a diverse library of small molecules for inhibition of the development of larvae of the parasitic nematode Haemonchus contortus led to the identification of a 1-methyl-1H-pyrazole-5-carboxamide derivative with an IC50 of 0.29 μM. Medicinal chemistry optimization targeted modifications on the left-hand side (LHS), middle section, and right-hand side (RHS) of the scaffold in order to elucidate the structure-activity relationship (SAR). Strong SAR allowed for the iterative and directed assembly of a focus set of 64 analogues, from which compound 60 was identified as the most potent compound, inhibiting the development of the fourth larval (L4) stage with an IC50 of 0.01 μM. In contrast, only 18% inhibition of the mammary epithelial cell line MCF10A viability was observed, even at concentrations as high as 50 μM.

Carbon tetrabromide mediated oxidative cyclocondensation of ketones and thioureas: An easy access to 2-aminothiazoles

A simple, mild, and efficient one-pot method for the synthesis of substituted 2-aminothiazoles has been reported. The reaction involves the formation of sulfenyl bromide as an umpolung intermediate of nucleophilic sulfur, which is responsible for C-S bond formation leading to oxidative cyclization of ketones and thioureas to furnish the desired products. Carbon tetrabromide was used as a convenient and mild brominating reagent under basic condition at room temperature to give 2-aminothiazoles in good to excellent yields.

NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS AND USES THEREOF

The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L2, are defined in th