3464-18-4Relevant articles and documents
Stereochemical studies. XLV. A novel regiospecific ring opening of optically active 2 substituted 1 tosylaziridines
Chyi Tseng,Terashima,Yamada
, p. 166 - 170 (1977)
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Stereoselective One-Pot Synthesis of cis-1,2-Dicyanoalkenes from 1,1-Bis(benzenesulfonyl)alkenes and KCN
Zhang, Yue,Wei, Yi,Li, Shen,Ma, Jun-An
, p. 199 - 203 (2019/01/04)
An efficient synthesis of cis-1,2-dicyanoalkenes by the reaction of 1,1-bis(benzenesulfonyl)alkenes with KCN was developed. This reaction was conducted in the presence of tetrabutylammonium bromide and NH4Cl/K3PO4 under phase-transfer conditions. A series of cis-1,2-dicyanoalkenes were obtained in good to high yields. Further transformation of the obtained product allows for access to imide and dicarboxylic acid compounds.
Synthetic derivatives of isoquinoline, dicarboxylic acid imides and thioimides as bioactive compounds
Solecka, Jolanta,Rajnisz, Aleksandra,Postek, Magdalena,Laudy, Agnieszka E.,Szawka?o, Joanna,Czarnocki, Zbigniew
, p. 1181 - 1189 (2016/10/17)
This study is a continuation of a research program aimed at identifying potent drugs against bacterial infections, in which a series of organic compounds: dicarboxylic acid imides and thioimides, isoquinoline derivatives and open chain compounds, were examined for antimicrobial properties against Staphylococcus aureus and Escherichia coli. In effect of this investigation, the most active compounds (35-40, 47) were selected for in vitro tests against fourteen clinically important pathogenic isolates, the methicillin resistant Staphylococcus aureus (MRSA) and several reference Gram-negative bacteria: Proteus vulgaris, Pseudomonas aeruginosa, Klebsiella pneumonia, Stenotrophomonas maltophilia, and Acinetobacter baumannii. The obtained data revealed that seven compounds (three dithioimides, 35, 39, 47, and four thioimides, 36-38, 40) exhibit effective antibacterial activity against the tested Staphylococcus aureus MSSA and MRSA strains. Among them, dicarboxylic acid thioimides 37 and 38 were proven to be the most active.