3464-68-4

Basic information

• Product Name: N-[(7S)-1-hydroxy-2,3,10-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide
• Synonyms: acetamide, N-[(7S)-5,6,7,9-tetrahydro-1-hydroxy-2,3,10-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-
• CAS NO: 3464-68-4
• Molecular Formula: C₂₁H₂₃NO₆
• Molecular Weight: 385.4104
• Mol File: 3464-68-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 744.2°C at 760 mmHg
• Flash Point: 403.9°C
• Density: 1.31g/cm³
• Vapor Pressure: 6.65E-23mmHg at 25°C
• Refractive Index: 1.61
• CAS DataBase Reference: N-[(7S)-1-hydroxy-2,3,10-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(7S)-1-hydroxy-2,3,10-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide(3464-68-4)
• EPA Substance Registry System: N-[(7S)-1-hydroxy-2,3,10-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide(3464-68-4)

Safety Data

• Hazardous Substances Data: 3464-68-4(Hazardous Substances Data)

Upstream product

• 3306-60-3 N-[(7S)-2,3,10-trimethoxy-1-((methyl)carbonyloxy)-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide 
• 64-86-8 colchicine 

Downstream Products

• 1057403-99-2 N-[(7S)-2,3,10-trimethoxy-9-oxo-1-((pyridin-3-yl)methoxy)-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide 

Relevant articles and documents

METHODS AND USES OF COLCHICINE DERIVATIVES

Colchicine derivative(s), method(s) and use(s) thereof for treatment of inflammation. In certain embodiments, the colchicine derivative is a compound of Formula I: (I)

The efficacy of new colchicine derivatives and viability of the T-Lymphoblastoid cells in three-dimensional culture using 19F MRI and HPLC-UV ex vivo

The paper describes ex vivo applications of colchicine derivatives for the treatment of human T-Lymphoblastoid (CEM) cells. Moreover, the role of the substitutions of ring A at C-1 and C-7 side chain of colchicine analogues was probed by the synthesis and examination of their effects on the three-dimensional (3-D) CEM cells' growth. The CEM cells were cultured in the hollow fiber bioreactor (HFB) device. We used 1H and 19F magnetic resonance imaging (MRI) to monitor changes in 3-D CEM cell culture. 19F MRI was used for visualization of the cellular uptake of new fluorine derivatives. Before and after treatment CEM cells profile was investigated with high performance liquid chromatography (HPLC-UV). Crown Copyright