346433-97-4

Basic information

• Product Name: 2-Bromo-4-fluoro-5-nitroaniline
• Synonyms: 2-Bromo-4-fluoro-5-nitroaniline
• CAS NO: 346433-97-4
• Molecular Formula: C₆H₄BrFN₂O₂
• Molecular Weight: 235.0105632
• Mol File: 346433-97-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 102.3-104.5 °C
• Boiling Point: 350.6±37.0 °C(Predicted)
• Appearance: /
• Density: 1.896±0.06 g/cm3(Predicted)
• PKA: 0.38±0.10(Predicted)
• CAS DataBase Reference: 2-Bromo-4-fluoro-5-nitroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-4-fluoro-5-nitroaniline(346433-97-4)
• EPA Substance Registry System: 2-Bromo-4-fluoro-5-nitroaniline(346433-97-4)

Safety Data

• Hazardous Substances Data: 346433-97-4(Hazardous Substances Data)

Usage

Description

2-Bromo-4-fluoro-5-nitroaniline is a chemical compound with the molecular formula C6H4BrFN2O2. It is a derivative of aniline, featuring a bromine atom, a fluorine atom, and a nitro group attached to the benzene ring. 2-Bromo-4-fluoro-5-nitroaniline is recognized for its high reactivity and is utilized in various applications across different industries.

Uses

Used in Pharmaceutical Industry:
2-Bromo-4-fluoro-5-nitroaniline serves as an intermediate in the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Bromo-4-fluoro-5-nitroaniline is utilized in the production of pesticides and other agrochemicals. Its reactivity and chemical properties make it a valuable intermediate for creating effective and targeted agricultural products.
Used in Organic Chemistry Research:
2-Bromo-4-fluoro-5-nitroaniline is also employed as a research compound in organic chemistry. Its distinct characteristics facilitate studies on chemical reactions and mechanisms, furthering scientific understanding and innovation in the field.
Used in Dye and Pigment Production:
2-Bromo-4-fluoro-5-nitroaniline is used as an intermediate in the production of dyes and pigments. Its ability to form various chemical bonds makes it suitable for creating a wide range of colorants used in different industries, including textiles, plastics, and printing.

Upstream product

• 1003-98-1 2-bromo-4-fluoroaniline 

Downstream Products

• 1309833-21-3 2-Cyclopropyl-4-fluoro-5-nitroaniline 
• 1309831-17-1 N₂-{4-cyclopropyl-6-fluoro-3-[4-methyl-1,2,3,4-tetrazol-5-one-1-yl]phenyl}-5-fluoro-N₄-(2,2,6,6-tetramethylpiperidin-4-yl)-2,4-pyrimidinediamine 
• 1309831-18-2 2-(4-cyclopropyl-2-fluoro-5-(4-methyl-5-oxo-4,5-dihydro-1H-tetrazol-1-yl)phenylamino)-4-(2,2,6,6-tetramethylpiperidin-4-ylamino)pyrimidine-5-carbonitrile 
• 1309831-19-3 1-{2-Cyclopropyl-4-fluoro-5-[5-fluoro-4-(1,2,2,6,6-pentamethyl-piperidin-4-ylamino)-pyrimidin-2-ylamino]-phenyl}-4-methyl-1,4-dihydro-tetrazol-5-one 
• 1309831-20-6 2-[4-Cyclopropyl-2-fluoro-5-(4-methyl-5-oxo-4,5-dihydro-tetrazol-1-yl)-phenylamino]-4-(1,2,2,6,6-pentamethyl-piperidin-4-ylamino)-pyrimidine-5-carbonitrile 
• 1309831-14-8 1-(2-Bromo-4-fluoro-5-nitrophenyl)-1H-tetrazol-5(4H)-one 
• 1309831-15-9 1-(2-bromo-4-fluoro-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one 
• 1309831-16-0 1-(5-amino-2-cyclopropyl-4-fluorophenyl)-4-methyl-1H-tetrazol-5(4H)-one 
• 1309833-20-2 1-(2-cyclopropyl-4-fluoro-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one 
• 1309833-22-4 1-(2-cyclopropyl-4-fluoro-5-nitrophenyl)-1H-tetrazol-5(4H)-one 
• 1309832-95-8 1-(2-Cyclopropyl-4-fluoro-5-nitrophenyl)-4-isopropyl-1H-tetrazol-5(4H)-one 
• 1309832-96-9 1-(5-Amino-2-cyclopropyl-4-fluorophenyl)-4-isopropyl-1H-tetrazol-5(4H)-one 
• 1309832-98-1 1-(5-Amino-2-cyclopropyl-4-fluorophenyl)-1H-tetrazol-5(4H)-one 
• 1309832-92-5 1-(2-cyclopropyl-4-fluoro-5-nitrophenyl)-4-(trideuteriomethyl)-1H-tetrazol-5(4H)-one 

Relevant articles and documents

Amino pyrimidine compound and preparation method and application thereof

The invention relates to an amino pyrimidine compound and a preparation method and application thereof. The amino pyrimidine compound has a structure as shown in a formula I. The formula is shown in the description. The compound is an inhibitor of an epidermal growth factor receptor (EGFR) kinase. The invention further relates to a medicine composition comprising the compound, a preparation methodand application thereof in preparation of anti-tumor medicines.

PROTEIN KINASE C INHIBITORS AND USES THEREOF

This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.