346451-15-8

Basic information

• Product Name: 1,4-BIS[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE DIHYDROCHLORIDE
• Synonyms: 1,4-BIS[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE DIHYDROCHLORIDE;Buclizine HCl IMpurity-A(BP/EP);1,4-Bis[^a-(4-chlorophenyl)benzyl]piperazine dihydrochloride, 97%;Cetirizine IMpurity D;Piperazine, 1,4-bis[(4- chlorophenyl)phenylMethyl]-;1,4-Bis[alpha-(4-chlorophenyl)benzyl]piperazine dihydrochloride;Cetirizine Dihydrochloride impurity D
• CAS NO: 346451-15-8
• Molecular Formula: C30H30Cl4N2
• Molecular Weight: 560.38
• Product Categories: Aromatics, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 346451-15-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 270-275 °C(Press: 1 Torr)
• Appearance: White/Solid
• Density: 1.228±0.06 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, Refrigerator, Under inert atmosphere
• Solubility: Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly, Heated), Methanol (Sli
• PKA: 5.85±0.10(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: 1,4-BIS[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE DIHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-BIS[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE DIHYDROCHLORIDE(346451-15-8)
• EPA Substance Registry System: 1,4-BIS[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE DIHYDROCHLORIDE(346451-15-8)

Safety Data

• Hazardous Substances Data: 346451-15-8(Hazardous Substances Data)

Usage

Description

1,4-BIS[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE DIHYDROCHLORIDE, also known as Buclizine impurity, is a chemical compound derived from the antiemetic agent Buclizine (B689450). It is characterized by its molecular structure that includes chlorophenyl and phenylmethyl groups attached to a piperazine core, with two hydrochloride ions associated with it. 1,4-BIS[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE DIHYDROCHLORIDE is typically found as an impurity in the synthesis or formulation of Buclizine.

Uses

Used in Pharmaceutical Industry:
1,4-BIS[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE DIHYDROCHLORIDE is used as an impurity in the production of Buclizine, an antiemetic agent. Its presence is significant for quality control and safety assessments, as impurities can affect the efficacy, safety, and regulatory approval of the final drug product. 1,4-BIS[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE DIHYDROCHLORIDE is important for ensuring the purity and quality of Buclizine, which is used to treat nausea and vomiting.
In the context of pharmaceutical development and manufacturing, understanding and controlling the levels of impurities like 1,4-BIS[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE DIHYDROCHLORIDE is crucial for maintaining the overall quality and safety of the drug Buclizine. This impurity may also be a subject of research for potential side effects or interactions with the main active pharmaceutical ingredient (API) in the drug formulation.

Upstream product

• 110-85-0 piperazine 
• 134-83-8 1-chloro-4-(chloro(phenyl)methyl)benzene 
• 303-26-4 N-(4-chlorobenzhydryl)piperazine 

Relevant articles and documents

Efficient synthesis of deuterium labeled hydroxyzine and aripiprazole

Hydroxyzine and aripiprazole are active pharmaceutical ingredients that have been largely acknowledged for their antipsychotic properties. Deuterium labeled isotopes of hydroxyzine and aripiprazole are internal standards that can aid in the further research of non-isotopic forms via quantification analysis using HPLC-MS/MS. The synthesis of hydroxyzine-d8 was accomplished by coupling piperazine-d8 with 4-chlorobenzhydryl chloride followed by the reaction of the first intermediate with 2-(2-chloroethoxy) ethanol to afford 11.7% of hydroxyzine-d8 with 99.5% purity. The synthesis of aripiprazole-d8 was also achieved in two steps. 1,4-Dibromobutane-d8 reacted with 7-hydroxy-3,4-dihydro-2(1H)-quinolinone. The first intermediate was then coupled with 1-(2, 3-dichlorophenyl)piperazine hydrochloride to produce 33.4% of aripiprazole-d8 with 99.93% purity.