346600-34-8

Basic information

• Product Name: (3-chloro-4-fluoro-phenyl)-(7-methyl-7H-pyrrolo [2,3-d]pyrimidin-4-yl)-amine
• Synonyms: (3-chloro-4-fluoro-phenyl)-(7-methyl-7H-pyrrolo [2,3-d]pyrimidin-4-yl)-amine
• CAS NO: 346600-34-8
• Molecular Weight: 276.701
• Mol File: 346600-34-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (3-chloro-4-fluoro-phenyl)-(7-methyl-7H-pyrrolo [2,3-d]pyrimidin-4-yl)-amine(CAS DataBase Reference)
• NIST Chemistry Reference: (3-chloro-4-fluoro-phenyl)-(7-methyl-7H-pyrrolo [2,3-d]pyrimidin-4-yl)-amine(346600-34-8)
• EPA Substance Registry System: (3-chloro-4-fluoro-phenyl)-(7-methyl-7H-pyrrolo [2,3-d]pyrimidin-4-yl)-amine(346600-34-8)

Safety Data

• Hazardous Substances Data: 346600-34-8(Hazardous Substances Data)

Upstream product

• 367-21-5 3-chloro-4-fluorophenylamine 
• 7781-10-4 4-Chlor-7-methyl-7H-pyrrolo<2,3-d>pyrimidin 
• 3680-69-1 4-chloro-1H-pyrrolo[2,3-d]pyrimidine 
• 3680-71-5 7-deazahypoxanthine 

Downstream Products

• 865364-83-6 4-(3-chloro-4-fluoro-phenylamino)-7-methyl-5,7-dihydro-pyrrolo [2,3-d]pyrimidin-6-one 

Relevant articles and documents

Rational design of 4,5-disubstituted-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-ones as a novel class of inhibitors of epidermal growth factor receptor (EGF-R) and Her2(p185(erbB)) tyrosine kinases.

A novel class of 4,5-disubstituted-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-ones has been discovered as potent and selective inhibitors of the EGF-R tyrosine kinase family. These compounds selectively inhibit EGF-R kinase activity at low nanomolar concentration and tyrosine autophosphorylation in cells expressing EGF-R or Her2 (p185(erbB)). Structure-activity relationships (SARs) for this class of compounds are presented.