346605-61-6

Basic information

• Product Name: N-[6-Amino-2-(2-ethoxyphenyl)-4-oxo-5-propyl-4,5-dihydro-pyrimidin-5-yl]-acetamide
• Synonyms: N-[6-Amino-2-(2-ethoxyphenyl)-4-oxo-5-propyl-4,5-dihydro-pyrimidin-5-yl]-acetamide
• CAS NO: 346605-61-6
• Molecular Weight: 330.387
• Mol File: 346605-61-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-[6-Amino-2-(2-ethoxyphenyl)-4-oxo-5-propyl-4,5-dihydro-pyrimidin-5-yl]-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[6-Amino-2-(2-ethoxyphenyl)-4-oxo-5-propyl-4,5-dihydro-pyrimidin-5-yl]-acetamide(346605-61-6)
• EPA Substance Registry System: N-[6-Amino-2-(2-ethoxyphenyl)-4-oxo-5-propyl-4,5-dihydro-pyrimidin-5-yl]-acetamide(346605-61-6)

Safety Data

• Hazardous Substances Data: 346605-61-6(Hazardous Substances Data)

Upstream product

• 56548-09-5 2-acetylamino-2-cyano-valeric acid ethyl ester 
• 18637-00-8 2-ethoxy-benzamidine hydrochloride 
• 90877-70-6 ethyl 2-acetamido-2-cyanoacetate 

Relevant articles and documents

Comparison of different heterocyclic scaffolds as substrate analog PDE5 inhibitors

Several different heterocyclic systems were compared as PDE5 inhibitor scaffolds. In addition to the known 3H-imidazo[5,1-f][1,2,4]triazin-4-ones and pyrazolopyrimidinones, isomeric imidazo[1,5-a][1,3,5]triazin-4(3H)-ones were also shown to be potent and selective PDE inhibitor scaffolds with in vivo activity. SAR trends were elucidated for sulfonamide derivatives with generality across different scaffolds.