346730-61-8Relevant articles and documents
Urotensin-II receptor antagonists: Synthesis and SAR of N-cyclic azaalkyl benzamides
Jin, Jian,An, Ming,Sapienza, Anthony,Aiyar, Nambi,Naselsky, Diane,Sarau, Henry M.,Foley, James J.,Salyers, Kevin L.,Knight, Steven D.,Keenan, Richard M.,Rivero, Ralph A.,Dhanak, Dashyant,Douglas, Stephen A.
scheme or table, p. 3950 - 3954 (2009/05/07)
SAR exploration of the central diamine, benzyl, and terminal aminoalkoxy regions of the N-cyclic azaalkyl benzamide series led to the identification of very potent human urotensin-II receptor antagonists such as 1a with a Ki of 4 nM. The synthesis and structure-activity relationships (SAR) of N-cyclic azaalkyl benzamides are described.
