3469-09-8

Basic information

• Product Name: 2,3-DIHYDRO-6-METHOXY-1H-INDEN-1-OL
• Synonyms: 2,3-DIHYDRO-6-METHOXY-1H-INDEN-1-OL;6-METHOXY-2,3-DIHYDRO-1H-INDEN-1-OL
• CAS NO: 3469-09-8
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.2
• Mol File: 3469-09-8.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,3-DIHYDRO-6-METHOXY-1H-INDEN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIHYDRO-6-METHOXY-1H-INDEN-1-OL(3469-09-8)
• EPA Substance Registry System: 2,3-DIHYDRO-6-METHOXY-1H-INDEN-1-OL(3469-09-8)

Safety Data

• Hazardous Substances Data: 3469-09-8(Hazardous Substances Data)

Usage

General Description

2,3-DIHYDRO-6-METHOXY-1H-INDEN-1-OL is a chemical compound with the molecular formula C10H12O2. It is a colorless to pale yellow liquid that is commonly used as a fragrance ingredient in various consumer products such as perfumes, lotions, and soaps. It is naturally occurring in various essential oils, including rose and jasmine, and is also produced synthetically for commercial use. 2,3-DIHYDRO-6-METHOXY-1H-INDEN-1-OL has a floral, woody, and slightly sweet odor, making it a popular choice for adding fragrance to a wide range of products. Additionally, it is known for its ability to enhance and stabilize the scent of other fragrance components and is often used as a fixative in perfume formulations.

Upstream product

• 13623-25-1 6-methoxy-2,3-dihydro-1H-inden-1-one 
• 1929-29-9 3-(4-methoxyphenyl)propanoic acid 
• 123-11-5 4-methoxy-benzaldehyde 
• 62803-47-8 6-hydroxy-1-indanone 

Downstream Products

• 475475-77-5 1-bromo-6-methoxy-indan 
• 128226-43-7 1-chloro-6-methoxyindane 
• 13623-25-1 6-methoxy-2,3-dihydro-1H-inden-1-one 
• 935248-15-0 1-{6-[5-(4-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-indanyl}-piperazine 
• 935248-14-9 1-{6-[5-(4-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-indanyl}-4-acetyl-piperazine 
• 831191-89-0 (1aR,6aS)-3-methoxy-6,6a-dihydro-1aH-indeno[1,2-b]oxirene 
• 91789-13-8 6-methoxy-1,2-epoxyindan 
• 91789-14-9 (1R,2R)-6-Methoxy-1-((E)-1-phenylsulfanyl-oct-2-enyl)-indan-2-ol 
• 91789-15-0 (1R,2R)-1-((E)-1-Benzenesulfinyl-oct-2-enyl)-6-methoxy-indan-2-ol 
• 39989-39-4 7-methoxyisoquinoline 

Relevant articles and documents

Isolation of a major metabolite (i-OHAP) of aprindine and its identification as N-[3-(N,N-diethylamino)propyl]-N-phenyl-2-aminoindan-5-ol

i-OHAP, a major metabolite of aprindine (AP), was isolated by TLC from rat feces and identified as N-13-(N,N-diethylamino)propyl]-N-phenyl-2- aminoindan-5-ol, based on 1H-NMR, the H-H correlation spectroscopy (COSY) spectrum, MS and LC-MS. Its

Synthesis of Indole-Dihydroisoquinoline Sulfonyl Ureas via Three-Component Reactions

Isoquinolines activated with sulfamoyl chlorides were reacted with indoles in a 3-component reaction to generate a library of dihydroisoquinoline derivatives. Using a differential protecting group strategy, products could be further derivatised. Synthesis of isoquinoline starting materials using several different methods is also described.

Total Synthesis of (-)-Daphenylline

Total synthesis of (-)-daphenylline, a hexacyclic Daphniphyllum alkaloid, was achieved. Construction of the tricyclic DEF ring system was initiated by asymmetric Negishi coupling followed by an intramolecular Friedel-Crafts reaction. Installation of a side chain onto the tricyclic core was carried out through Sonogashira coupling, stereocontrolled Claisen rearrangement by taking advantage of the characteristic conformation of the tricyclic DEF core, and the stereoselective alkylation of a lactone. After the introduction of a glycine unit, the ABC ring system was stereoselectively constructed through intramolecular cycloaddition of the cyclic azomethine ylide.