34715-92-9

Basic information

• Product Name: 2-(4-NITROBENZOYL)THIOPHENE
• Synonyms: 2-(4-NITROBENZOYL)THIOPHENE;TIMTEC-BB SBB006262;(4-nitrophenyl)-(2-thienyl)methanone;(4-nitrophenyl)(2-thienyl)methanone;(4-nitrophenyl)-thiophen-2-ylmethanone;(4-nitrophenyl)-thiophen-2-yl-methanone;Methanone, (4-nitrophenyl)(2-thienyl)-
• CAS NO: 34715-92-9
• Molecular Formula: C₁₁H₇NO₃S
• Molecular Weight: 233.24
• Mol File: 34715-92-9.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 407.6°C at 760 mmHg
• Flash Point: 200.3°C
• Appearance: /
• Density: 1.381g/cm³
• Vapor Pressure: 7.46E-07mmHg at 25°C
• Refractive Index: 1.641
• CAS DataBase Reference: 2-(4-NITROBENZOYL)THIOPHENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-NITROBENZOYL)THIOPHENE(34715-92-9)
• EPA Substance Registry System: 2-(4-NITROBENZOYL)THIOPHENE(34715-92-9)

Safety Data

• Hazardous Substances Data: 34715-92-9(Hazardous Substances Data)

Usage

General Description

2-(4-Nitrobenzoyl)thiophene is a chemical compound with the molecular formula C14H9NO3S. It is a derivative of thiophene, a heterocyclic compound containing a sulfur atom. The compound contains a nitrobenzoyl group attached to the thiophene ring, making it a member of the nitrobenzoylthiophene class of compounds. This chemical may have various applications in organic synthesis and medicinal chemistry, and its properties and uses may be of interest to researchers in these fields.

InChI:InChI=1/C11H7NO3S/c13-11(10-2-1-7-16-10)8-3-5-9(6-4-8)12(14)15/h1-7H

Upstream product

• 188290-36-0 thiophene 
• 122-04-3 4-nitro-benzoyl chloride 
• 7499-53-8 5-nitro-2-(thiophene-2-carbonyl)-benzoic acid 
• 5980-89-2 di-[2]thienyl-mercury 
• 636-98-6 p-nitrobenzene iodide 
• 201230-82-2 carbon monoxide 
• 37496-13-2 2-(trimethylstannyl)thiophene 
• 1003-09-4 2-bromothiophene 
• 555-16-8 4-nitrobenzaldehdye 
• 6165-68-0 thiophene boronic acid 
• 62-23-7 4-nitro-benzoic acid 
• 20895-79-8 2-Thienyl(p-toluenesulfonyl)methane 
• 350-46-9 4-Fluoronitrobenzene 
• 5466-84-2 4-nitrophthalic anhydride 

Downstream Products

• 39055-79-3 2-(3-cyano-4-hydroxybenzoyl)thiophene 
• 25706-30-3 2-(4-Aminobenzoyl)thiophene 
• 1202186-02-4 1-(4-nitrophenyl)-1-(2-thienyl)-4-methyl-4-(tetrahydropyran-2-yloxy)-pent-2-yn-1-ol 

Relevant articles and documents

Mechanochemical Solvent-Free Suzuki–Miyaura Cross-Coupling of Amides via Highly Chemoselective N?C Cleavage

Although cross-coupling reactions of amides by selective N?C cleavage are one of the most powerful and burgeoning areas in organic synthesis due to the ubiquity of amide bonds, the development of mechanochemical, solid-state methods remains a major challe

Preparation of acylthiophenes by iron(III) chloride catalyzed reactions of tris(2-thienyl)stibanes with acyl chlorides

The reactions of tris(2-thienyl)stibanes with various acyl chlorides, using a catalytic amount of iron(III) chloride, afforded 2-acylthiophenes. Iron(III) chloride is presumed to act as a Lewis acid, and the ipso substituent of each 2-thienyl group of tris(2-thienyl)stibane is replaced with an acyl group. The reaction is highly atom-efficient in that all three thiophene rings of tris(2-thienyl)stibane take part in the reaction. The reaction procedure is so simple that it can also be carried out under solvent-free and aerobic conditions.

TFAA/H3PO4-Mediated C-2 acylation of thiophene: A direct synthesis of known and novel thiophene derivatives of pharmacological interest

A number of aliphatic and aromatic carboxylic acids were reacted with thiophene in the presence of trifluoroacetic anhydride and H3PO 4 to give a variety of acylated thiophenes in good to excellent yields. The methodology was used to prepare known nonsteroidal anti-inflammatory drug-based novel compounds of potential pharmacological significances. Molecular modeling studies were carried out by using nonsteroidal anti-inflammatory drug-based thiophene derivatives to assess their cyclooxygenase inhibiting potential in silico. On the basis of docking studies followed by subsequent in vitro assay, indomethacin-based thiophene derivative was identified as a novel cyclooxygenase-2 inhibitor with balanced selectivity.