347196-12-7

Basic information

• Product Name: CHEMBRDG-BB 4022584
• Synonyms: CHEMBRDG-BB 4022584;2-CHLORO-N-(3-FLUORO-2-METHYL-PHENYL)-ACETAMIDE;2-chloro-N-(3-fluoro-2-methylphenyl)acetamide(SALTDATA: FREE);2-chloro-N-(3-fluoro-2-methyl-phenyl)ethanamide
• CAS NO: 347196-12-7
• Molecular Formula: C₉H₉ClFNO
• Molecular Weight: 201.63
• Mol File: 347196-12-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 315.7°C at 760 mmHg
• Flash Point: 144.7°C
• Appearance: /
• Density: 1.306g/cm³
• Vapor Pressure: 0.00043mmHg at 25°C
• Refractive Index: 1.563
• CAS DataBase Reference: CHEMBRDG-BB 4022584(CAS DataBase Reference)
• NIST Chemistry Reference: CHEMBRDG-BB 4022584(347196-12-7)
• EPA Substance Registry System: CHEMBRDG-BB 4022584(347196-12-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 347196-12-7(Hazardous Substances Data)

Usage

General Description

CHEMBRDG-BB 4022584 is a chemical compound with the molecular formula C16H13FN2O and a molecular weight of 268.29 g/mol. It is a pyridine derivative with potential antineoplastic and antiangiogenic activities. The compound has been identified as a potent inhibitor of vascular endothelial growth factor receptor 2 (VEGFR-2), a key mediator of angiogenesis, making it a potential candidate for the development of anti-angiogenic drugs for cancer treatment. In addition, it has also shown activity against tumor cell growth and proliferation. Further studies are needed to evaluate its potential as a therapeutic agent for cancer and other angiogenesis-related diseases.

InChI:InChI=1/C9H9ClFNO/c1-6-7(11)3-2-4-8(6)12-9(13)5-10/h2-4H,5H2,1H3,(H,12,13)

Upstream product

• 443-86-7 3-fluoro-2-methylaniline 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 952587-03-0 2-chloro-N-(3-fluoro-2-methyl-6-nitrophenyl)acetamide 
• 485832-96-0 3-fluoro-2-methyl-6-nitroaniline 
• 952587-08-5 7-fluoro-8-methyl-2-(methyloxy)quinoxaline 
• 952587-06-3 7-fluoro-8-methyl-2(1H)-quinoxalinone 
• 952587-04-1 2-cyano-N-(3-fluoro-2-methyl-6-nitrophenyl)acetamide 

Relevant articles and documents

Synthesis and Biological Evaluation of Dithiobisacetamides as Novel Urease Inhibitors

Thirty-eight disulfides containing N-arylacetamide were designed and synthesized in an effort to develop novel urease inhibitors. Biological evaluation revealed that some of the synthetic compounds exhibited strong inhibitory potency against both cell-free urease and urease in intact cell with low cytotoxicity to mammalian cells even at concentration up to 250 μM. Of note, 2,2′-dithiobis(N-(2-fluorophenyl)acetamide) (d7), 2,2′-dithiobis(N-(3,5-difluorophenyl)acetamide) (d24), and 2,2′-dithiobis(N-(3-fluorophenyl)acetamide) (d8) were here identified as the most active inhibitors with IC50 of 0.074, 0.44, and 0.81 μM, showing 32- to 355-fold higher potency than the positive control acetohydroxamic acid. These disulfides were confirmed to bind urease without covalent modification of the cysteine residue and to inhibit urease reversibly with a mixed inhibition mechanism. They also showed very good anti-Helicobacter pylori activities with d8 showing a comparable potency to the clinical used drug amoxicillin. The impressive in vitro biological profile indicated their immense potential as therapeutic agents to tackle H. pylori caused infections.

AZATRICYCLIC COMPOUNDS AND THEIR USE

Tricyclic nitrogen containing compounds),of formula (I) or a pharmaceutically, acceptable salt, solvate and/or N-oxide thereof: and their use as antibacterials.

Novel piperidine and piperazine derivatives

The invention provides piperidine and piperazine derivatives of general formula (I), processes for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therapy