347335-60-8

Basic information

• Product Name: 4-chloro-2-phenyl-N-formyl-1,2-dihydroquinoline
• Synonyms: 4-chloro-2-phenyl-N-formyl-1,2-dihydroquinoline
• CAS NO: 347335-60-8
• Molecular Weight: 269.73
• Mol File: 347335-60-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-chloro-2-phenyl-N-formyl-1,2-dihydroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-2-phenyl-N-formyl-1,2-dihydroquinoline(347335-60-8)
• EPA Substance Registry System: 4-chloro-2-phenyl-N-formyl-1,2-dihydroquinoline(347335-60-8)

Safety Data

• Hazardous Substances Data: 347335-60-8(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 68-12-2 N,N-dimethyl-formamide 
• 78396-00-6 1-(2-aminophenyl)-3-phenylprop-2-en-1-one 

Downstream Products

• 1039-51-6 2,4-diphenylquinoline 
• 4979-79-7 4-chloro-2-phenylquinoline 
• 612-96-4 2-Phenylquinoline 

Relevant articles and documents

The Vilsmeier cyclization of 2′-azido and 2′-aminochalcones - A mild one pot synthesis of 2-aryl-4-chloroquinoline and its N-formyl-1,2-dihydro derivatives

The Vilsmeier cyclization of 2′-aminochalcones provides a mild one pot synthesis of 2-aryl-4-chloro-N-formyl-1,2-dihydroquinolines. The scope of the reaction has been extended for the synthesis of quinolines themselves, by replacing 2′-aminochalcones with 2′-azidochalcones as the starting material. The yields are reasonably good and a plausible mechanism for the formation of the products in each case has been discussed.

Intramolecular cyclization of 2′-aminochalcones by halomethyleniminium salts derived from btc/dmf

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