3477-93-8

Basic information

• Product Name: Benzoic acid, 4-[(hydroxyimino)methyl]-
• CAS NO: 3477-93-8
• Molecular Formula: C8H7NO3
• Molecular Weight: 165.148
• Mol File: 3477-93-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-[(hydroxyimino)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[(hydroxyimino)methyl]-(3477-93-8)
• EPA Substance Registry System: Benzoic acid, 4-[(hydroxyimino)methyl]-(3477-93-8)

Safety Data

• Hazardous Substances Data: 3477-93-8(Hazardous Substances Data)

Upstream product

• 53148-13-3 4-(hydroxyiminomethyl)benzoic acid methyl ester 
• 1571-08-0 methyl 4-formylbenzoate 
• 17333-91-4 diazotiertes 4-Amino-benzaldehyd 
• 619-66-9 4-Carboxybenzaldehyde 
• 874-86-2 4-cyanobenzyl chloride 
• 74231-65-5 p-cyano-1-(dichloromethyl)benzene 
• 56-91-7 p-aminomethylbenzoic acid 

Downstream Products

• 1394822-23-1 C₁₂H₁₀N₂O₅ 
• 26726-03-4 4-(chloro-hydroxyimino-methyl)-benzoic acid 
• 56-91-7 p-aminomethylbenzoic acid 
• 619-65-8 4-cyanobenzoic Acid 
• 1404492-00-7 Zn(p-carboxybenzaldehyde oxime(-1H))2 

Relevant articles and documents

Cascade Process for Direct Transformation of Aldehydes (RCHO) to Nitriles (RCN) Using Inorganic Reagents NH2OH/Na2CO3/SO2F2 in DMSO

A simple, mild, and practical process for direct conversion of aldehydes to nitriles was developed feathering a wide substrate scope and great functional group tolerability (52 examples, over 90% yield in most cases) using inorganic reagents (NH2OH/Na2CO3/SO2F2) in DMSO. This method allows for transformations of readily available, inexpensive, and abundant aldehydes to highly valuable nitriles in a pot, atom, and step-economical manner without transition metals. This protocol will serve as a robust tool for the installation of cyano-moieties to complicated molecules.

SO 2 F 2 -Promoted Dehydration of Aldoximes: A Rapid and Simple Access to Nitriles

A rapid, simple and mild process for the dehydration of aldoximes to give the corresponding nitriles, which utilizes SO 2 F 2 as an efficient reagent, has been developed. A variety of (hetero)arene, alkene, alkyne and aliphatic aldoximes proceeded with high efficiency to afford nitriles in excellent to quantitative yields with great functional group compatibilities in acetonitrile under ambient conditions. Furthermore, an eco-friendly synthetic protocol to access nitriles from aldehydes with ortho -, meta - and para -nitrile groups was also described in aqueous methanol by using inorganic base Na 2 CO 3, and a one-pot synthetic strategy to generate nitriles from aldehydes was proved to be feasible.

PREPARATION METHOD OF 4-AMINOMETHYLBENZOIC ACID

The present invention relates to a preparation method of 4-aminomethylbenzoic acid comprising the following steps: preparing 4-carboxylbenzaldehyde or an alkyl ester thereof (methyl 4-formyl benzoate); reacting the 4-carboxylbenzaldehyde or an alkyl ester thereof (methyl 4-formyl benzoate) with hydroxyamine to oximate the same; and contact reducing 4-carboxylbenzaldehyde oxime or an alkyl ester oxime thereof obtained by the oximation, through hydrogen in a sodium hydroxide aqueous solution. Since methyl 4-hydroxyiminomethylbenzoate is reacted as a raw material in the presence of an alkali, hydrogen of a relatively low pressure can be used and a purification process is also simple, thereby enabling preparation of 4-aminomethylbenzoic acid with a low cost and high yield.