348-52-7 Usage
Description
1-Fluoro-2-iodobenzene is an organic compound that belongs to the class of aromatic halides. It is a clear, colorless to light yellow liquid with the molecular formula C6H4FI. 1-Fluoro-2-iodobenzene is characterized by the presence of a fluorine atom at the 1st position and an iodine atom at the 2nd position on a benzene ring, which imparts unique chemical properties to the molecule.
Uses
Used in Pharmaceutical Industry:
1-Fluoro-2-iodobenzene is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical properties make it a valuable building block for the development of new drugs with potential therapeutic applications.
Used in Chemical Synthesis:
1-Fluoro-2-iodobenzene is used as a starting material for the synthesis of various organic compounds, including bridged biphenyl compounds, 1-fluoro-8-methylbiphenylene, and 4-fluoro-5-methylfluorene. These compounds have potential applications in various industries, such as materials science and electronics.
Used in Suzuki Reaction:
1-Fluoro-2-iodobenzene is utilized in the Suzuki reaction, a widely used cross-coupling reaction in organic chemistry. This reaction allows for the formation of carbon-carbon bonds, which are essential for the synthesis of complex organic molecules, including pharmaceuticals, agrochemicals, and advanced materials.
Used in Synthesis of Chiral O-Phosphanophenyl Sulfoxides:
1-Fluoro-2-iodobenzene is also used in the synthesis of chiral o-phosphanophenyl sulfoxides, which are important intermediates in the preparation of various biologically active compounds and pharmaceuticals. These chiral compounds play a crucial role in the development of enantiomerically pure drugs with improved efficacy and reduced side effects.
Synthesis Reference(s)
Synthetic Communications, 20, p. 1701, 1990 DOI: 10.1080/00397919008053092
Check Digit Verification of cas no
The CAS Registry Mumber 348-52-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,4 and 8 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 348-52:
(5*3)+(4*4)+(3*8)+(2*5)+(1*2)=67
67 % 10 = 7
So 348-52-7 is a valid CAS Registry Number.
348-52-7Relevant articles and documents
Selective C-H Iodination of (Hetero)arenes
Tanwar, Lalita,B?rgel, Jonas,Lehmann, Johannes,Ritter, Tobias
supporting information, p. 5024 - 5027 (2021/06/30)
Iodoarenes are versatile intermediates and common synthetic targets in organic synthesis. Here, we present a strategy for selective C-H iodination of (hetero)arenes with a broad functional group tolerance. We demonstrate the utility and differentiation to other iodination methods of supposed sulfonyl hypoiodites for a set of carboarenes and heteroarenes.
Application of trivalent iodine compounds as catalysts in Bal-Schiemann reaction
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Paragraph 0153; 0158, (2018/10/19)
The invention discloses an application of trivalent iodine compounds shown in formula I and/or II in the description and used as catalysts in Bal-Schiemann reaction. The trivalent iodine compounds areused as the catalysts in the Bal-Schiemann reaction, so that the Bal-Schiemann reaction can be conducted at room temperature or near room temperature when a thermochemical method is used, and the reaction has mild reaction conditions, wide substrate use range and short reaction time, and is safe and easy to operate, products are easy to separate, and raw materials are simple and low in toxicity.
Hypervalent Iodine(III)-Catalyzed Balz–Schiemann Fluorination under Mild Conditions
Xing, Bo,Ni, Chuanfa,Hu, Jinbo
, p. 9896 - 9900 (2018/07/31)
An unprecedented hypervalent iodine(III) catalyzed Balz–Schiemann reaction is described. In the presence of a hypervalent iodine compound, the fluorination reaction proceeds under mild conditions (25–60 °C), and features a wide substrate scope and good functional-group compatibility.
