348-66-3

Basic information

• Product Name: D-ornithine
• Synonyms: (2R)-2,5-diaminopentanoic acid;CPD-217
• CAS NO: 348-66-3
• Molecular Formula: C₅H₁₂N₂O₂
• Molecular Weight: 133.17042
• EINECS: 206-482-0
• Mol File: 348-66-3.mol
• Article Data: 26

Chemical Properties

• Melting Point: 140 °C
• Boiling Point: 308.7±32.0 °C(Predicted)
• Appearance: /
• Density: 1.165±0.06 g/cm3(Predicted)
• PKA: 2.45±0.24(Predicted)
• CAS DataBase Reference: D-ornithine(CAS DataBase Reference)
• NIST Chemistry Reference: D-ornithine(348-66-3)
• EPA Substance Registry System: D-ornithine(348-66-3)

Safety Data

• Hazardous Substances Data: 348-66-3(Hazardous Substances Data)

Usage

Description

D-ornithine, also known as the D-enantiomer of ornithine, is an intermediate metabolite that plays a crucial role in the urea cycle. It is an amino acid derivative that is essential for various biological processes and has been found to have potential applications in different industries.

Uses

Used in Pharmaceutical Industry:
D-ornithine is used as a therapeutic agent for promoting wound healing and enhancing immune function. It is particularly effective in treating conditions such as burns, trauma, and sepsis, where rapid tissue repair and immune support are critical.
Used in Sports Nutrition:
In the sports nutrition industry, D-ornithine is used as a supplement to improve athletic performance and support muscle growth. It is believed to enhance the production of growth hormone and insulin-like growth factor-1 (IGF-1), which are essential for muscle development and recovery.
Used in Cosmetics:
D-ornithine is also used in the cosmetics industry for its potential anti-aging and skin-protective properties. It may help improve skin elasticity and reduce the appearance of fine lines and wrinkles, making it a valuable ingredient in anti-aging skincare products.
Used in Research:
In the field of scientific research, D-ornithine serves as an important compound for studying the urea cycle and related metabolic pathways. It is used as a research tool to better understand the role of ornithine in various biological processes and to develop new therapeutic strategies for various diseases.

Upstream product

• 1892-22-4 3-aminopiperidin-2-one 
• 70-26-8 D-ornithine 
• 542-32-5 (R,S)-2-aminoadipic acid 
• 157-06-2 D-arginine 
• 74-79-3 L-arginine 
• 627-77-0 citrulline 
• 15920-89-5 N^α-carbamoyl-L-arginine 
• 4435-48-7 butane-1,1,4-tricarboxylic acid 
• 5440-42-6 ethyl 2-acetamido-4-cyano-2-ethoxycarbonylbutanoate 
• 7438-77-9 Orn-δ-NOH 
• 3928-25-4 N,N'-bis-(pyridine-2-carbonyl)-ornithine 
• 26464-30-2 2-chloro-5-phthalimido-pentanoic acid 
• 7664-41-7 ammonia 
• 7732-18-5 water 

Downstream Products

• 5058-01-5 3-hydroxytetrahydro-2H-pyran-2-one 
• 2000-59-1 5-amino-2-oxo-valeric acid 
• 110-60-1 1,4-diaminobutane 
• 74-79-3 L-arginine 
• 70-26-8 2,5-diaminopentanoic acid 
• 102082-20-2 (+/-)-N-[3-(2,5-dioxo-1-phenyl-imidazolidin-4-yl)-propyl]-N'-phenyl-urea 
• 13594-51-9 D-citrulline 
• 5724-81-2 1-pyrroline 
• 2640-58-6 N²-benzyloxycarbonyl-L-ornithine 
• 97974-52-2 (2S,5S,12R)-12-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2-isobutyl-3,7,13-trioxo-1,4,8-triaza-cyclotridecane-5-carboxylic acid amide 
• 96382-72-8 H-Tyr-D-Orn[*]-Phe-Asp[*]-NH2 
• 106732-42-7 (2S,5S,12R,15S,18S,25R)-12,25-Bis-[(S)-2-amino-3-(4-hydroxy-phenyl)-propionylamino]-2,15-dibenzyl-3,7,13,16,20,26-hexaoxo-1,4,8,14,17,21-hexaaza-cyclohexacosane-5,18-dicarboxylic acid diamide 
• 95610-96-1 (5S,13R)-13-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-3,8,14-trioxo-1,4,9-triaza-cyclotetradecane-5-carboxylic acid amide 
• 2274-58-0 N,N'-di(benzyloxycarbonyl)-D-ornithine 

Relevant articles and documents

Catenulobactins A and B, Heterocyclic Peptides from Culturing Catenuloplanes sp. with a Mycolic Acid-Containing Bacterium

The production of two new heterocyclic peptide isomers, catenulobactins A (1) and B (2), in cultures of Catenuloplanes sp. RD067331 was significantly increased when it was cocultured with a mycolic acid-containing bacterium. The planar structures and absolute configurations of the catenulobactins were determined based on NMR/MS and chiral-phase GC-MS analyses. Catenulobactin B (2) displayed Fe(III)-chelating activity and moderate cytotoxicity against P388 murine leukemia cells.

FUNCTIONALIZED FLUORINE CONTAINING PHTHALOCYANINE MOLECULES

Functionalized fluorine containing phthalocyanine molecules, methods of making, and methods of use in diagnostic applications and disease treatment are disclosed herein. In some embodiments, the fluorine containing phthalocyanine molecules are functionalized with a reactive functional group or at least one cancer-targeting ligand (CTL). The CTL can facilitate more efficient binding and/or internalization to a cancer cell than to a healthy cell. The CTL can inhibit expression of oncoprotein in some embodiments. The pthalocyanine moiety can be used in diagnostic applications, such as fluorescence labeling of a cancer cell, and/or treatment applications, such as catalyzing formation of a reactive oxygen species (ROS) which can contribute to cell death of a cancer cell.

Lysine racemase from a lactic acid bacterium, Oenococcus oeni: Structural basis of substrate specificity

Oenococcus oeni, a lactic acid bacterium, possesses a lysine racemase, which has a specific activity towards basic amino acids. A comparison of amino acid residues around the active site suggested that Ile222 and Tyr354 of the Geobacillus stearothermophilus alanine racemase, which shares 60% sequence similarity with lysine racemase, were replaced by Thr224 and Trp355 in the O. oeni lysine racemase. T224I/W355Y double mutations significantly decreased the activity of lysine racemase, whereas I222T/Y354W double mutations endowed alanine racemase with lysine racemization activity. These results suggest that the two residues play an important role in lysine racemization.