34801-09-7

Basic information

• Product Name: 2'-AMINOACETANILIDE
• Synonyms: N-(2-azanylphenyl)ethanamide;2'-Aminoacetanilide ,98%;N-(2-Aminophenyl)acetamide, 2-(Acetamido)aniline, N-Acetylphenylene-1,2-diamine;N-Acetyl-1,2-phenylenediamine 2'-Acetamidoaniline;2-AMinoactanilide;2'-Aminoacetanilide 98%;Acetanilide, 2-amino- (8CI);N-(2-aminophenyl)ethanamide
• CAS NO: 34801-09-7
• Molecular Formula: C₈H₁₀N₂O
• Molecular Weight: 150.18
• Product Categories: Benzenes;Nitrogen Compounds;Organic Building Blocks;Protected Amines;AMINEPRIMARY;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 34801-09-7.mol
• Article Data: 50

Chemical Properties

• Melting Point: 133-137 °C(lit.)
• Boiling Point: 271.72°C (rough estimate)
• Flash Point: 172.4 °C
• Appearance: /
• Density: 1.1392 (rough estimate)
• Refractive Index: 1.6180 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 14.73±0.70(Predicted)
• Water Solubility: 107.5g/L(22 oC)
• CAS DataBase Reference: 2'-AMINOACETANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-AMINOACETANILIDE(34801-09-7)
• EPA Substance Registry System: 2'-AMINOACETANILIDE(34801-09-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 34801-09-7(Hazardous Substances Data)

Usage

Chemical Properties

White Powder

Uses

2′-Aminoacetanilide may be used in the preparation of:2-Methylbenzimidazole.N-(2-(1,3-Dimethyl-2,4-dioxo-5-phenyl-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)phenyl)-5-methylfuran-2-carboxamide, a potent cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor.Azobenzothiazole dyes, N-[2-(6-nitrobenzothiazol-2-ylazo)phenyl]acetamide and N-[2-(benzothiazol-2-ylazo)phenyl]acetamide.

General Description

2′-Aminoacetanilide (2-aminoacetanilide, o-aminoacetanilide) can be prepared by the catalytic hydrogenation of 2-nitroacetanilide using 10%Pd/C (palladium/carbon).

Upstream product

• 552-32-9 o-nitroacetanilide 
• 2050-85-3 N,N'-(o-phenylene)di(acetamide) 
• 144-62-7 oxalic acid 
• 108-24-7 acetic anhydride 
• 95-54-5 1,2-diamino-benzene 
• 551-93-9 2-aminoacetophenone 
• 19165-25-4 2-methyl-6-bromo-4H-3,1-benzoxazine-4-one 
• 7647-01-0 hydrogenchloride 
• 64-19-7 acetic acid 
• 64-17-5 ethanol 
• 75-36-5 acetyl chloride 
• 88-74-4 2-nitro-aniline 
• 507-09-5 tiolacetic acid 
• 62-53-3 aniline 

Downstream Products

• 102025-08-1 acetic acid-(2-trans-cinnamylidenamino-anilide) 
• 107682-65-5 acetic acid-[2-amino-5-(3-nitro-phenylazo)-anilide] 
• 107682-66-6 acetic acid-{2-[3-(2-nitro-phenyl)-triazenyl]-anilide} 
• 615-15-6 2-Methyl-1H-benzimidazole 
• 18773-93-8 1-acetyl-1H-benzotriazole 
• 106592-59-0 acetic acid-{2-[(1,3-dimethyl-2,4,6-trioxo-tetrahydro-pyrimidin-5-ylidenemethyl)-amino]-anilide} 
• 2050-85-3 N,N'-(o-phenylene)di(acetamide) 
• 122773-86-8 acetoacetic acid N-(2-acetamidophenyl)amide 
• 103207-24-5 acetic acid-[2-(3-oxo-3-phenyl-propenylamino)-anilide] 
• 51815-54-4 Bis-<2-acetamino-phenyl>-harnstoff 
• 6121-10-4 1-<2-Acetylamino-phenyl>-biuret 
• 91181-53-2 ethyl 2-acetamidophenylcarbamate 
• 84293-19-6 3-<(o-acetamidophenyl)carbamoyl>norbornadiene-2-carboxylic acid 
• 81840-10-0 2-acetylamino-β-ethoxyacryloanilide 

Relevant articles and documents

Proximity Histidine Labeling by Umpolung Strategy Using Singlet Oxygen

While electrophilic reagents for histidine labeling have been developed, we report an umpolung strategy for histidine functionalization. A nucleophilic small molecule, 1-methyl-4-arylurazole, selectively labeled histidine under singlet oxygen (1O2) generation conditions. Rapid histidine labeling can be applied for instant protein labeling. Utilizing the short diffusion distance of 1O2 and a technique to localize the 1O2 generator, a photocatalyst in close proximity to the ligand-binding site, we demonstrated antibody Fc-selective labeling on magnetic beads functionalized with a ruthenium photocatalyst and Fc ligand, ApA. Three histidine residues located around the ApA binding site were identified as labeling sites by liquid chromatography-mass spectrometry analysis. This result suggests that 1O2-mediated histidine labeling can be applied to a proximity labeling reaction on the nanometer scale.

Method for reducing aromatic nitro into arylamine

The invention relates to a method for reducing aromatic nitro to arylamine. The method comprises the following steps: (1) taking an aromatic nitro compound as a raw material, water as a hydrogen source, a palladium compound, cheap and easy to obtain, as a catalyst and tetrahydroxydiboron as an additive to reduce nitro to obtain a product; (2) taking the aromatic nitro compound as the raw material, a copper salt, cheap and easy to obtain, as the catalyst, the tetrahydroxydiboron as the additive to reduce the nitro to obtain a product; and (3) taking the aromatic nitro compound as the raw material, water as the hydrogen source, and the tetrahydroxydiboron as the additive, without needing a metal catalyst, to reduce the nitro to obtain a product. A preparation method for the arylamine, which is provided by the invention, is mild in reaction condition, low in costs, environment-friendly, high in yield, and suitable for industrial production.