34803-67-3

Basic information

• Product Name: 1-(4-METHYL-PYRIDIN-2-YL)-PIPERAZINE
• Synonyms: 1-(4-METHYL-PYRIDIN-2-YL)-PIPERAZINE;1-[2-(4-METHYLPYRIDYL)]PIPERAZINE;AKOS BBS-00003642;Piperazine, 1-(4-methyl-2-pyridinyl)- (9CI);1-(4-Methylpyridin-2-yl)piperazine 97%;1-(4-METHYL-PYRIDIN-2-YL)-PIPERAZINE >98%;4-Methyl-2-(piperazin-1-yl)pyridine;1-(4-Methylpyridin-2-yl)piperazine97%
• CAS NO: 34803-67-3
• Molecular Formula: C₁₀H₁₅N₃
• Molecular Weight: 177.25
• Product Categories: PIPERIDINE;pharmacetical;piperazines
• Mol File: 34803-67-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 114-116°C 0,1mm
• Flash Point: 163.6 °C
• Appearance: /
• Density: 1.059 g/cm³
• Vapor Pressure: 5.56E-05mmHg at 25°C
• Refractive Index: 1.543
• PKA: 9.09±0.27(Predicted)
• CAS DataBase Reference: 1-(4-METHYL-PYRIDIN-2-YL)-PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-METHYL-PYRIDIN-2-YL)-PIPERAZINE(34803-67-3)
• EPA Substance Registry System: 1-(4-METHYL-PYRIDIN-2-YL)-PIPERAZINE(34803-67-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: UN3259
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 34803-67-3(Hazardous Substances Data)

Usage

Description

1-(4-METHYL-PYRIDIN-2-YL)-PIPERAZINE, also known as a piperazine analog, is a chemical compound that selectively targets the D4 receptor. This receptor plays a crucial role in central nervous system (CNS) pathologies, making 1-(4-METHYL-PYRIDIN-2-YL)-PIPERAZINE a promising candidate for various pharmaceutical applications.

Uses

Used in Pharmaceutical Industry:
1-(4-METHYL-PYRIDIN-2-YL)-PIPERAZINE is used as a selective D4 receptor agonist for the treatment of CNS pathologies. Its high selectivity for the D4 receptor makes it a potential candidate for developing targeted therapies for various neurological and psychiatric disorders.
Used in Research and Development:
1-(4-METHYL-PYRIDIN-2-YL)-PIPERAZINE is also used as a research tool in the field of neuroscience. It helps researchers understand the role of the D4 receptor in CNS pathologies and aids in the development of new drugs targeting this receptor.
Used in Drug Discovery:
1-(4-METHYL-PYRIDIN-2-YL)-PIPERAZINE serves as a lead compound in drug discovery, particularly for the development of novel therapeutics targeting the D4 receptor. Its selective interaction with the receptor can lead to the creation of more effective and safer medications for treating CNS-related conditions.

InChI:InChI=1/C10H15N3/c1-9-2-3-12-10(8-9)13-6-4-11-5-7-13/h2-3,8,11H,4-7H2,1H3

Downstream Products

• 148489-98-9 2-(4-methoxy-phenyl)-1-{2-[4-(4-methylpyridin-2-yl)piperazin-1-yl]ethyl}-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline 

Relevant articles and documents

OGA INHIBITOR COMPOUNDS

The present invention relates to O-GlcNAc hydrolase (OGA) inhibitors. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which inhibition of OGA is beneficial, such as tauopathies, in particular Alzheimer's disease or progressive supranuclear palsy; and neurodegenerative diseases accompanied by a tau pathology, in particular amyotrophic lateral sclerosis or frontotemporal lobe dementia caused by C9ORF72 mutations; or alpha synucleinopathies, in particular Parkinson's disease, dementia due to Parkinson's (or neurocognitive disorder due to Parkinson's disease), dementia with Lewy bodies, multiple system atrophy, or alpha synucleinopathy caused by Gaucher's disease.