34840-50-1

Basic information

• Product Name: 4-morpholine
• Synonyms: 4-morpholine
• CAS NO: 34840-50-1
• Molecular Weight: 284.766
• Mol File: 34840-50-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-morpholine(34840-50-1)
• EPA Substance Registry System: 4-morpholine(34840-50-1)

Safety Data

• Hazardous Substances Data: 34840-50-1(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 333-20-0 potassium thioacyanate 
• 122-01-0 4-chloro-benzoyl chloride 
• 1147550-11-5 ammonium thiocyanate 
• 16794-67-5 p-chlorobenzoyl isothiocyanate 

Downstream Products

• 189453-13-2 4-(4-chlorophenyl)-2-(4-nitrophenyl)-6-morpholino-2H-1,3,5-thiadiazine 
• 189452-39-9 4-chloro-N-[morpholino(thiocarbonyl)]-N'-(4-nitrobenzyl)benzamidine 
• 189452-99-1 N-bis[(ethoxycarbonyl)methyl]-4-chloro-N'-[morpholino(thiocarbonyl)]benzamidine 
• 114171-41-4 [4-(4-Chloro-phenyl)-2-morpholin-4-yl-thiazol-5-yl]-phenyl-methanone 
• 59849-37-5 (4-chloro-phenyl)-[4-(4-chloro-phenyl)-2-morpholin-4-yl-thiazol-5-yl]-methanone 

Relevant articles and documents

Synthesis and exploration of 2-morpholino-4-phenylthiazol-5-yl acrylamide derivatives for their effects against carbonic anhydrase I, II, IX and XII isoforms as a non-sulfonamide class of inhibitors

Novel series of 2-morpholino-4-phenylthiazol-5-yl acrylamide derivatives (8a–s) have been synthesized and explored as a non-sulfonamide class of carbonic anhydrase (CA, EC 4.2.1.1) inhibitors. The newly synthesized molecules were evaluated for their CA in

Synthesis of mono- and N,N-disubstituted thioureas and N-acylthioureas

1-Benzotriazole-1-carbothioamide (2), prepared from 1-cyanobenzotriazole (1) and hydrogen sulfide, reacts with amines to give thioureas 3a-e. Reactions of (benzotriazol-1-yl)carboximidamides 4a-d,f-j and acyl- 5a-f,i-k or arylaminocarbonyl- 5g,h (benzotri

N'-Substituted N-Acyl- and N-Imidoyl-thioureas: Preparation and Conversion of N',N'-Disubstituted Compounds into 2-(N,N-Disubstituted Amino)thiazol-5-yl Ketones

Known methods were developed to give convenient general procedures for preparing N-acyl-N'-mono- and -N',N'-disubstituted thioureas from acid chlorides, and related N-imidoyl thioureas from imidoyl chlorides.In the products from three acid chlorides and ammonium thiocyanate the acyl isothiocyanates did not appear to be accompained by the isomeric thiocyanates.Treatment of N-(anilino)benzylidene-N',N'-disubstituted thioures with chloroacetone in the presence of triethylamine leads to 5-acetyl-4-phenyl-2-(N,N-disubstituted amino)thiazoles.In contrast, the corresponding N-benzoyl thioureas form only small amounts of these compounds; the main products are the 5-benzoyl-4-methyl isomers, and this unexpected outcome requires a revision of the literature.It is thought that formation of the 5-benzoyl-4-methylthiazoles involves N-C(4) fission of a cyclic intermediate to give an open-chain intermediate in which nucleophilic attack can occur at either the acetyl or the benzoyl group.One of the latter intermediates was generated directly from 2-acetyl-2-bromoacetophenone and N-methyl-N-phenylthiourea, and found to give the 5-benzoyl-4-methyl- and 5-acetyl-4-phenyl-thiazoles as the major and minor products, respectively.