34892-10-9Relevant articles and documents
A kinetic study into the hydrolysis of the ochratoxins and analogues by carboxypeptidase A
Stander,Steyn,Van der Westhuizen,Payne
, p. 302 - 304 (2007/10/03)
The hydrolyses of the ochratoxins and analogues by carboxypeptidase A were assessed. This was done by measuring the amount of phenylalanine formed with liquid chromatography coupled to tandem electrospray mass spectrometry. The kinetic data of ochratoxin A, ochratoxin B, and the synthetic bromo-ochratoxin B were compared to the values of a number of synthesized structure analogues, namely, ochratoxin A methyl ester, ochratoxin B methyl ester, N-(2-hydroxybenzoyl)phenylalanine, N-(5-chloro-2-hydroxybenzoyl)phenylalanine, N-(5-bromo-2-hydroxybenzoyl)phenylalanine, and N-(5-fluoro-2-hydroxybenzoyl)phenylalanine. The halogen-containing analogues had lower turnovers than their des-halo analogues. There are no substantial differences in the kinetic data between the different halogen-containing analogues.
Crystal Structures and Conformational Analysis of Ochratoxin A and B: Probing the Chemical Structure causing Toxicity
Bredenkamp, Martin W.,Dillen, Jan L. M.,Rooyen, Petrus H. van,Steyn, Pieter S.
, p. 1835 - 1840 (2007/10/02)
Studies performed on two metabolites from Aspergillus ochraceus, ochratoxin A (1) and B (2), have yielded information related to the steric, conformational, and electric considerations that could contribute to the different toxicities of these metabolites