349-49-5 Usage
Description
4-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE is an organic compound with the molecular formula C4H4F3N2S. It is a derivative of thiazol-2-ylamine, featuring a trifluoromethyl group attached to the 4-position of the thiazol ring. 4-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE is known for its potential applications in the pharmaceutical and chemical industries due to its unique structural properties and reactivity.
Uses
Used in Pharmaceutical Industry:
4-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in HIV Treatment:
4-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE is used as a starting material for the preparation of phenethylthiazolylthiourea analogs, which have been identified as HIV-1 reverse transcriptase inhibitors. These inhibitors play a crucial role in the development of antiretroviral drugs, helping to combat the HIV virus by blocking the replication process.
Used in Diabetes Management:
4-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE can also be used to synthesize 2-amino benzamide derivatives, which act as allosteric glucokinase activators. These activators are important in the regulation of glucose metabolism and have potential applications in the treatment of type 2 diabetes. By enhancing the activity of glucokinase, these derivatives can help improve insulin secretion and glucose homeostasis, contributing to better diabetes management.
Check Digit Verification of cas no
The CAS Registry Mumber 349-49-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,4 and 9 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 349-49:
(5*3)+(4*4)+(3*9)+(2*4)+(1*9)=75
75 % 10 = 5
So 349-49-5 is a valid CAS Registry Number.
InChI:InChI=1/C4H3F3N2S/c5-4(6,7)2-1-10-3(8)9-2/h1H,(H2,8,9)
349-49-5Relevant articles and documents
A novel access to 4-trifluoromethyl-1,3-thiazole derivatives via an intermediate thiocarbonyl ylide
Obijalska, Emilia,B?aszczyk, Magdalena,Kowalski, Marcin K.,Mlostoń, Grzegorz,Heimgartner, Heinz
, p. 35 - 40 (2019/02/25)
A Lewis acid catalyzed reaction of trifluoroacetyldiazomethane (CF3COCHN2) with thiourea occurs in boiling THF solution in the presence of BF3·OEt2 yielding 2-amino-4-trifluoromethyl-1,3-thiazole in a fair yield
Thiazolides as novel antiviral agents. 2. Inhibition of hepatitis c virus replication
Stachulski, Andrew V.,Pidathala, Chandrakala,Row, Eleanor C.,Sharma, Raman,Berry, Neil G.,Lawrenson, Alexandre S.,Moores, Shelley L.,Iqbal, Mazhar,Bentley, Joanne,Allman, Sarah A.,Edwards, Geoffrey,Helm, Alison,Hellier, Jennifer,Korba, Brent E.,Semple, J. Edward,Rossignol, Jean-Francois
supporting information; experimental part, p. 8670 - 8680 (2012/02/16)
We report the activities of a number of thiazolides [2-hydroxyaroyl-N- (thiazol-2-yl)amides] against hepatitis C virus (HCV) genotypes IA and IB, using replicon assays. The structure-activity relationships (SARs) of thiazolides against HCV are less predic
CARBACEPHEM β-LACTAM ANTIBIOTICS
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Page/Page column 92, (2010/04/06)
Carbacephem -lactam antibiotics having structure (I) are disclosed, including stereoisomers, pharmaceutically acceptable salts, esters and prodrugs thereof, wherein Ar1, Ar2, R1 and R2 are as defined herein. The compounds are useful for the treatment of bacterial infections, in particular those caused by methicillin-resistant Staphylococcus spp.